Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Image Credit:Arch Clin Infect Dis
Outline
Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran
Authors
Abstract
Background: Human papillomavirus (HPV) is associated with various benign and malignant lesions including genital condyloma and anogenital cancer. The presence of HPV-DNA was studied in archival biopsies of high- and intermediate-risk lesions for cervical carcinoma in women referred to Mirza hospital in Tehran.
Patients and methods: Totally, 105 Iranian archived biopsies collected during February and November 2006. HPVDNA was isolated from the biopsies and detected by means of consensus polymerase chain reaction (PCR) detecting a broad spectrum of genital HPV types.
Results: Totally, 26 samples (24.7%) were positive for oncogenic HPV-DNA. Risk of HPV infection was significantly higher in biopsies obtained from patients with confirmed squamous cell carcinoma (SCC) who started sexual activity more recently (≤4 years ago) when compared with those who started earlier (≥10 years ago). HPV-16 was more frequently detected in biopsies of younger women.
Conclusion: HPV was more frequently detected in young women. Our data confirm the usefulness of this method for detection of HPV in archival biopsies.
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References
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Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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