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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population
Authors
Liming Wu1, 2, Lin Chen3, Lin Zhou1, 2, Haiyang Xie1, 2, Bajin Wei3, Shengyong Yin1, 2, Yufu Ye3, Weijia Fang4, Shusen Zheng1, 2,*
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China
3School of Medicine, Zhejiang University, Hangzhou, China
4Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
*Corresponding Author: Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Hangzhou, China. Tel: +86- 57187236570, Fax: +86-57187236466, Email: shusenzheng@zju.edu.cn
Published online:Apr 30, 2011
Article type:Research Article
The editors have expressed concern about this article. See Expression of Concern for Association of Interleukin 18 Gene Promoter Polymorphisms with HBV Recurrence After Liver Transplantation in Han Chinese Population [Hepat Mon. 2011; 11 (6): e169683].
How to Cite:Wu L, Chen L, Zhou L, Xie H, Wei B, et al. Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population. Hepat Mon. 2011;11(6):e169683. doi:
Abstract
Background: There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production.
Objectives: To investigate the potential association of two polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL-18 gene with the risk of HBV recurrence after liver transplantation (LT) in Han Chinese patients.
Patients and Methods: IL-18 promoter genotyping was performed by the snapshot technique in 125 patients with HBV-related end-stage liver disease (ESLD) receiving LT in our center from 2004 to 2008.
Results: Among the study samples, no significant association between the IL-18 promoter polymorphisms ( 137G/C and 607C/A) or haplotypes and HBV recurrence after LT was found.
Conclusions: The polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL18 gene may not play a key role in HBV recurrence after LT in Han Chinese population, and may not be suitable predictors for HBV recurrence in clinical practice.
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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