Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection

Sodaif Moghaddam; Ali Haghdoost; Seyed Hoseini; Rashid Ramazani; Mohammad Rezazadehkermani

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Current Issue Accepted Manuscripts All Issues In Press Articles Search

Journal Information Boards and committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection

Author(s):

Sodaif Moghaddam,

Ali Haghdoost,

Seyed Hoseini,

Rashid Ramazani,

Mohammad Rezazadehkermani

^1,*

1Research Institute of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Hepatitis Monthly:Vol. 10, issue 4; 23-26

Published online:Jan 31, 2011

Article type:Research Article

Received:Mar 22, 2010

Accepted:Aug 11, 2010

How to Cite:Moghaddam S, Haghdoost A, Hoseini S, Ramazani R, Rezazadehkermani M. Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection.Hepat Mon.2011;10(4):e69923.

Abstract

Background: Occult hepatitis B infection (OBI) is a form of hepatitis in which there is an absence of detectable HBsAg, despite the presence of HBV-DNA in the peripheral blood of patients. It seems that non-effective or attenuated immune system responses against HBV lead to the development of OBI. Previous studies showed that the Fas/Fas ligand (FasL) system is an important death signaling pathway that is used by cytotoxic T lymphocytes to eradicate HBV from the liver.
Objectives: To investigate polymorphisms in the -670 region of the Fas gene in those with OBI.
Patients and Methods: The plasma samples from 3700 blood donors were tested for HBsAg and anti-HBs by ELISA. The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA by PCR. Those with HBV-DNA were diagnosed as OBI and PCR-RFLP technique was performed to examine polymorphisms within their Fas gene.
Results: 352 (9.5%) of 3700 blood samples were HBsAg-/anti-HBc+. HBV-DNA was detected in 57 (16.1%) of 352 HBsAg-/anti-HBc+ samples. Therefore, 57 HBsAg-/anti-HBc+/HBV-DNA+ patients were diagnosed as OBI. Patient and control groups had no significant differences in terms of the studied polymorphisms.
Conclusions: The functional polymorphisms in the promoter region of Fas gene are not associated with OBI. Therefore, it may be concluded that polymorphisms at the -670 position of the Fas gene do not have any critical effects on the immune response against HBV in OBI.

Implication for Health policy/practice/research/medical education:
The role of gene polymorphisms in patients with Hepatitis B virus infection is discussed in this study. Reading this article is suggested to all virolo¬gists, genetic specialists in the field of hepatology.

Please cite this paper as:
Arababadi MK, Mohammadzadeh A, Pourfathollah AA, Kennedy D. Polymorphisms within Fas gene are not associated with occult HBV infection. Hepat Mon. 2011;11(1):23-26.

Keywords

Hepatitis B infection

Fulltext

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 8
Last Update: 1 month ago
Scopus by Title (Ref): 0
Last Update: 1 month ago
CrossRef: 0
Last Update: 2 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Sodaif Moghaddam:[PubMed][Scholar]
Ali Haghdoost:[PubMed][Scholar]
Seyed Hoseini:[PubMed][Scholar]
Rashid Ramazani:[PubMed][Scholar]
Mohammad Rezazadehkermani:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection

Abstract

Fulltext

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 2 days ago