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Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Antithrombin-III as a Non-Invasive Marker of Chronic Liver Disease
Author(s):
1Department of Clinical Laboratory Diagnosis, National Medical Academy for Postgraduate Education, [email protected], Ukraine
2Department of Clinical Laboratory Diagnosis, National Medical Academy for Postgraduate Education, Ukraine
*Corresponding Author: Department of Clinical Laboratory Diagnosis, National Medical Academy for Postgraduate Education, [email protected], Ukraine. Tel: +380 44 4409680. Fax: +380 44 4569027. Email: [email protected]
Published online:Jun 30, 2009
Article type:Research Article
Received:Dec 09, 2008
Accepted:May 07, 2009
How to Cite:Sajjadieh M, Viunytska L. Antithrombin-III as a Non-Invasive Marker of Chronic Liver Disease. Hepat Mon. 2009;9(2):. doi:
Abstract
Background and Aims: Recently, many studies have reported that the plasma concentrations of natural anticoagulants, such as Antithrombin-III (AT-III), are altered in patients with chronic liver disease. In addition, the changes in the synthesis of AT-III occur in liver tissue and are associated with the extent of chronic hepatitis and cirrhosis.
Methods: In this study, we analyzed the plasma level of ??-III and serum activity of aminotransferase in 60 participants: 20 patients with chronic hepatitis, 20 patients with cirrhosis, and 20 healthy individuals (controls).
Results: Low levels of AT-III and elevated levels of aminotransferase activity were associated with both chronic hepatitis and cirrhosis. We found that among patients with elevated gamma glutamyl transferase (GGT) activity and chronic liver disease, the level of ??-III in plasma was significantly lower in patients with chronic cirrhosis than in patients with chronic hepatitis (P < 0.05) and the level of ??-III in plasma was lower in patients with liver disease in comparison to healthy participants (P < 0.001).
Conclusions: The level of AT-III in patients with chronic liver disease may be used as a non-invasive factor for the laboratory diagnosis of cirrhosis.
Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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