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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Serum Insulin-Like Growth Factor-I and Tumor Size in Patients with Metastatic Liver Cancer
Authors
Mohsen Masoodi1,*, Rahim Aghazadeh2, Mohammad Hossein Somi3, Ahmad Shavakhi4, Abbas Arjmand Shabestari2, Mohammad Reza Zali2
1Department of Internal Medicine, Hormozgan University of Medical Sciences, masoodi47@yahoo.com, Hormozgan, IR.Iran
2Research Center for Gastroenterology & Liver Diseases (RCGLD), Shaheed Beheshti University of Medical Sciences, Tehran, IR.Iran
3Tabriz Liver and Gastrointestinal Diseases Research Center (LGDRC), Tabriz University of Medical Sciences, Azarbayejan-e-Sharghi, IR.Iran
4Isfahan University of Medical Sciences, Isfahan, IR.Iran
*Corresponding Author: Department of Internal Medicine, Hormozgan University of Medical Sciences, masoodi47@yahoo.com, Hormozgan, IR.Iran. Tel: +98 912 3178080. Fax: +98 761 3348722. Email: masoodi47@yahoo.com
Published online:Sep 30, 2008
Article type:Research Article
Received:Nov 20, 2007
Accepted:Aug 26, 2008
How to Cite:Masoodi M, Aghazadeh R, Somi M, Shavakhi A, Shabestari A, et al. Serum Insulin-Like Growth Factor-I and Tumor Size in Patients with Metastatic Liver Cancer. Hepat Mon. 2008;8(3):. doi:
Abstract
Background and Aims: Insulin-like growth factor-I (IGF-1) is a liver-derived humoral factor, which has important anabolic and metabolic actions. Low serum concentrations of IGF-1 have been reported in patients with chronic liver disease, especially cirrhosis and hepatocellular carcinoma and metastatic liver cancer. The aim of our study was to evaluate any possible relationship between intensity of liver metastases on serum IGF-1 concentrations.
Methods: Serum IGF-1 were measured by ELIZA (III) in10 patients with uninodular or multinodular liver metastases and extension |£50% (group A) and 10 patients with multinodular or massive liver metastases and extension > 50% (group B) of liver size without liver failure.
Results: Serum IGF-1 concentration was significantly lower in the more sever metastatic group (group B) than the less sever metastatic group (group A) (121.40 ± 52.08 vs. 210.30 ± 42.59 ng/ml, respectively; P < 0.001).
Conclusions: Our findings suggest that the states of serum IGF-1 levels in patients with metastatic liver cancer may be a helpful finding for determining the severity of metastasis to the liver.
Highlights
Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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