Comparison of Immunogenicity of Low-Dose Intradermal Hepatitis B Vaccine with the Standard-Dose Intramuscular Vaccination in Young Healthy Iranian Adults

Batool Mood; Shahrokh Izadi; Masoud Salehi; Hamid Qaedi

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Current Issue Accepted Manuscripts All Issues In Press Articles Search

Journal Information Boards and committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Comparison of Immunogenicity of Low-Dose Intradermal Hepatitis B Vaccine with the Standard-Dose Intramuscular Vaccination in Young Healthy Iranian Adults

Author(s):

Batool Sharifi Mood^1,*,

Shahrokh Izadi²,

Masoud Salehi²,

Hamid Qaedi²

1Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, batoolsharifi@yahoo.com, IR-Iran

2Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, IR-Iran

Hepatitis Monthly:Vol. 8, issue 2; 111-114

Published online:Jun 30, 2008

Article type:Research Article

Received:Mar 07, 2008

Accepted:May 19, 2008

How to Cite:Mood B S, Izadi S, Salehi M, Qaedi H. Comparison of Immunogenicity of Low-Dose Intradermal Hepatitis B Vaccine with the Standard-Dose Intramuscular Vaccination in Young Healthy Iranian Adults.Hepat Mon.2008;8(2):111-114.

Abstract

Background and Aims: Although hepatitis B vaccine reliably induces immunity against hepatitis B virus (HBV), the cost of intramuscular (IM) vaccination has limited its use, particularly in many developing countries. Intradermal (ID) vaccination has been proposed as a cost-saving alternative method for administration of hepatitis B vaccine. However, the effectiveness of ID vaccination needs to be assessed in different ethnic groups.

Methods: From September 2006 to March 2008, 185 healthy anti-HBc-negative medical and nursing students at Zahedan University of Medical Sciences who had no history of vaccination against HBV, smoking or hepatitis were evaluated. They were randomly categorized into two groups. In group I (n=91), low-dose (4 |mg) recombinant hepatitis B vaccine (Euvax B, Korea) was given by intradermal route. In group II (n=94), the standard dose (20 mg) of the vaccine was administered intramuscularly at 0, 1, and 6 months. The groups were followed for a minimum of 7 months after the first vaccine dose and tested for anti-HBs titers by ELISA (Diasorin Bio Medica Kit, Saluugia, Italy).

Results: Seroprotective anti-HBs titers (titer >10 mIU/mL) were achieved in 79 (87%) students in group I and in 90 (96%) in group II (P=0.031). The difference was much pronounced when the two groups were compared for achieving an anti-HBs titer >300 mIU/mL (P<0.0001).

Conclusions: Although ID administration of 4-mg recombinant hepatitis B vaccine is effective, this route is less effective with lower immune response than the IM vaccination.

Keywords

Hepatitis B Vaccine

Immunogenicity

Intradermal Vaccination

Intramuscular Vaccination

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 6
Last Update: 1 month ago
Scopus by Title (Ref): 6
Last Update: 1 month ago
CrossRef: 0
Last Update: 2 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Batool Mood:[PubMed][Scholar]
Shahrokh Izadi:[PubMed][Scholar]
Masoud Salehi:[PubMed][Scholar]
Hamid Qaedi:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

Comparison of Immunogenicity of Low-Dose Intradermal Hepatitis B Vaccine with the Standard-Dose Intramuscular Vaccination in Young Healthy Iranian Adults

Abstract

Full Text

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 2 days ago