Seroprevalence of Hepatitis E in Patients with Chronic Liver Disease from East Azerbaijan, Iran

1Associate Professor of Gastroenterology, Liver and Gastrointestinal Diseases Research Center Imam Hospital, University Street, [email protected], IR-Iran

2Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, IR-Iran

3Department of Gastroenterology, Isfahan University of Medical Sciences, IR-Iran

Hepatitis Monthly:Vol. 7, issue 3; 127-130

Published online:Sep 30, 2007

Article type:Research Article

Received:Aug 19, 2007

Accepted:Oct 08, 2007

How to Cite:Somi M, Farhang S, Majid G, Shavakhi A, Pouri A. Seroprevalence of Hepatitis E in Patients with Chronic Liver Disease from East Azerbaijan, Iran. Hepat Mon. 2007;7(3):. doi:

Abstract

Background and Aims: Superinfection with HEV in patients with chronic liver disease (CLD) can cause severe hepatic decompensation leading to increased morbidity and mortality. This study aimed to determine seroprevalence of HEV infection among CLD patients compared to blood donors from Azerbaijan, north-west of Iran.
Methods: CLD patients and a group of age matched blood donors with normal liver function tests were evaluated for the presence of anti-HEV IgG antibody in their sera for evidence of hepatitis E. The risk factors were estimated.
Results: The mean age of CLD patients was 48 years (range: 10-87). 27.5% of patients were HEV IgG-positive. Among the controls 19.7% were positive for anti-HEV IgG. By multivariate analysis, there was no association between positive anti-HEV IgG and etiology of chronic liver disease, gender, literacy, accommodation, and number of family members in patients or controls. Mean age of patients infected with HEV in both groups was significantly more than the seronegative ones.
Conclusions: We found high seroprevalence of HEV-antibody among blood donors and CLD patients in our study, so we recommend more attention to hygiene of food and water. In addition, such patients should be informed about the potential risks and simple ways to prevent the disease in their regular life and travels. This issue must be concerned in cases of "acute on chronic" hepatitis in CLD patients.

Keywords

Hepatitis E

Seroprevalence

Chronic Liver Disease

Azerbaijan

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Author(s):

Mohammad Somi:[PubMed][Scholar]
Sara Farhang:[PubMed][Scholar]
Golnar Majid:[PubMed][Scholar]
Ahmad Shavakhi:[PubMed][Scholar]
Ali Pouri:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Seroprevalence of Hepatitis E in Patients with Chronic Liver Disease from East Azerbaijan, Iran

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