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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
The Prevalence of Thrombocytopenia in Patients with Chronic Hepatitis B and C
Authors
1Tehran Hepatitis Center, bita_behnava@yahoo.com, Tehran, IR.Iran
2Liver and Gastrointestinal Research Center, Baqiyatallah University of Medical Sciences & Tehran Hepatitis Center, Tehran, IR.Iran
*Corresponding Author: Tehran Hepatitis Center, bita_behnava@yahoo.com, Tehran, IR.Iran. Tel: +98 21 88980786. Fax: +98 21 88958048. Email: bita_behnava@yahoo.com
Published online:Dec 31, 2006
Article type:Research Article
Received:Apr 01, 2006
Accepted:Apr 18, 2006
How to Cite:Behnava B, Alavian S, Asl M. The Prevalence of Thrombocytopenia in Patients with Chronic Hepatitis B and C. Hepat Mon. 2006;6(2):. doi:
Abstract
Background and Aims:Thrombocytopenia is a relatively common extrahepatic manifestation of hepatitis c,even in the absence of cirrhosis.Also, thrombocytopenia has been reported in chronic HBV infection. The aims of present study were to evaluate the prevalence of thrombocytopenia in chronic HCV and HBV infection in the absence of cirrhosis and to assess the relationship between HBV and HCV infection and frequency of thrombocytopenia.
Methods: 438 patients (219 patients with chronic active hepatitis B and 123 inactive carriers of HBV and 96 patients with chronic HCV infection) were enrolled in this study. Thrombocytopenia was defined as platelet counts below 150,000/µl.
Results: The prevalence of thrombocytopenia was 17.7% in patients with chronic active hepatitis B and 10.6% in HBV inactive carriers, 13.3% in patients with chronic hepatitis C and 5.3% in control group. The prevalence of thrombocytopenia in chronic hepatitis B and C was significantly more than control group.
Conclusions: These results in Iran, with 2-3 million people with chronic HBV infection and around 400,000 with chronic HCV infection shows that HBV and HCV infections, even in the absence of cirrhosis, may be two causes of thrombocytopenia.
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Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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