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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
HBV DNA Viral Load and Chronic Hepatitis Infection in Different Stages
Authors
Bita Behnava1, Shervin Assari1, Mohsen Amini1, Bashir Hajibeigi1, Hassan Manzouri Jouybari1, Seyed Moayed Alavian
2,*
2,*1Tehran Hepatitis Center, Tehran, IR.Iran
2Department of Internal Medicine, Baqiyatallah University of Medical Sciences & Tehran Hepatitis Center, alavian@thc.ir, Tehran, IR.Iran
*Corresponding Author: Department of Internal Medicine, Baqiyatallah University of Medical Sciences & Tehran Hepatitis Center, alavian@thc.ir, Tehran, IR.Iran. Tel: +98 21 8896 7923. Fax: +98 21 8895 8048. Email: alavian@thc.ir
Published online:Dec 31, 2005
Article type:Research Article
How to Cite:Behnava B, Assari S, Amini M, Hajibeigi B, Jouybari H, et al. HBV DNA Viral Load and Chronic Hepatitis Infection in Different Stages. Hepat Mon. 2005;5(4):. doi:
Abstract
Background and Aims:The significance of hepatitis B virus (HBV) serum titers has been examined in several clinical situations. Although most studies addressing this question have shown a correlation between virus serum titer and severity of liver damage, some others have failed to show any correlation between them. The aim of the present study was to determine any correlation between HBV viral load and the severity of liver disease.
Methods:200 patients, including inactive carriers (n=104), patients with chronic active hepatitis (n=74: 55 HBeAg negative and 19 HBeAg positive) and with cirrhosis (n=22) entered the study. Quantitative serum HBV RNA assay was carried out using the PCR Amplicore technique.
Results: The mean age of the patients was 37 ± 12 years. A significant correlation was observed between HBV DNA viral load and ALT in cirrhotic patients (p=0.035, r=0.451). No correlation was observed between serum HBV DNA viral load and the histopathological score or grade, ALT or AST level in other CLD types (p>0.05). Conclusions: Our results indicate that the severity of liver disease is independent of serum levels of hepatitis B virus.The correlation between serum titers of hepatitis B virus and severity of liver disease clearly require further investigation.
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Copyright
© 2005, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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