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Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Evaluation of the Level of HBV Antibody Titer after HBV Vaccination among Children in Tehran, Iran
Author(s):
1Pediatric Hepatology Department, Cairo University, Cairo, Egypt
*Corresponding Author: Mortada El-Shabrawi, Cairo University, 3 Nablos Street, Off Shehab Street, Mohandesseen, Zip: 12411, Gairo, Egypt. Tell: +20123133705, Fax: +20237619012. E-mail: [email protected] Email: [email protected]
Published online:Jun 30, 2009
Article type:Brief Report
Received:Aug 21, 2008
Accepted:Jan 27, 2009
How to Cite:Isa M, El-Shabrawi M. Evaluation of the Level of HBV Antibody Titer after HBV Vaccination among Children in Tehran, Iran. Hepat Mon. 2011;11(5):. doi:
Abstract
Background and Aims: Hepatitis B infection is a serious public health problem worldwide. It has been shown that the levels of antibody to hepatitis B surface antigen (anti-HBs) decrease after vaccination. The main objective of this study was to assess the level of anti-HBs among children after primary vaccination against hepatitis B virus (HBV) in Tehran, Iran.
Methods: The study was conducted in four selected healthcare centers in Tehran during a 6-month period from September 2005 to March 2006 in Tehran. Blood samples collected from 165 healthy, 1- to 5-year-old children who had been vaccinated against HBV were tested for anti-HBs using enzyme-linked immunosorbent assay (ELISA).
Results: Approximately 47.9 % of the cases were male. Among the cases, the minimum and maximum titers of hepatitis B surface antibodies (HBsAb) were zero and 1000 m IU, respectively. The mean level of HBsAb titer in this study was 232.64 m IU, with a standard deviation of 278.711 m IU.
Conclusions: The results showed that HBsAb titer may decrease over time after vaccination. Finally, along with prevention and control strategies, ongoing investigation and monitoring of antibody levels against HBV in children and other age ranges is recommended.
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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