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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Efficacy of the Confidential Unit Exclusion Option in Blood Donors in Tehran, Iran, Determined by Using the Nucleic Acid Testing Method in 2008 and 2009
Authors
Elham Farhadi1, Ahmad Gharehbaghian2,*, Gharib Karimi1, Shahram Samiee1, Farzaneh Tavasolli1, Yahya Salimi1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, IR Iran
21) Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran.2) Medical Laboratory Sciences Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, gharehbaghian@sbmu.ac.ir, IR Iran
*Corresponding Author: 1) Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran.2) Medical Laboratory Sciences Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, gharehbaghian@sbmu.ac.ir, IR Iran. Tel: +98-2122737140. Fax: +98-2122721150. Email: gharehbaghian@sbmu.ac.ir
Published online:Nov 30, 2011
Article type:Research Article
Received:Jul 11, 2011
Accepted:Oct 20, 2011
How to Cite:Farhadi E, Gharehbaghian A, Karimi G, Samiee S, Tavasolli F, et al. Efficacy of the Confidential Unit Exclusion Option in Blood Donors in Tehran, Iran, Determined by Using the Nucleic Acid Testing Method in 2008 and 2009. Hepat Mon. 2011;11(11):. doi: https://doi.org/10.5812/kowsar.1735143X.778
Abstract
Background: In recent years, the confidential unit exclusion (CUE) option has been used to increase blood safety at blood transfusion centers in several countries. The epidemiologic characteristics of diseases and demographic characteristics of patients vary in different countries; therefore, we investigated whether the CUE option is useful in Iran. In this study, we determined the prevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) in CUE-positive and CUE-negative units, as well as the efficacy of the CUE option.
Objectives: The aim of this study was to evaluate the efficacy of the CUE option in reducing the prevalences of HBV and HCV in blood units.
Patients and Methods: All donors were tested for the HCV antibody (anti-HCV) and hepatitis B surface antigen (HBsAg). Supplemental tests were performed to confirm the presence of viruses in the units that tested positive. In total, 2000 units (1000 CUE-positive units and 1000 CUE-negative units) were tested using the nucleic acid testing (NAT) method. The prevalence of infectious markers was estimated in all demographic subgroups.
Results: The prevalences of HBV and HCV markers were higher in donors who opted for CUE than in those who did not. The CUE option had low sensitivity (21.5%) and positive predictive value (PPV; 20.9%) for the markers. Most of the donors who opted for CUE for the first time were men with low levels of education.
Conclusions: The CUE option has low sensitivity and PPV, and its effectiveness in reducing the transmission of infectious diseases through window-period units is minimal. The CUE process can be continued in Iran because Iran is geographically located in a region where HBV is endemic; however, higher levels of education are necessary to make this process effective.
Implication for health policy/practice/research/medical education:
The implications of the present study could be fruitful for policy makers in the domain of health particularly blood services.
Moreover, given controversial issues about the efficiency of CUE, the findings of this study would help up decision makers of blood services either adopt new plans and programs or make effective modifications.
Please cite this paper as:
Farhadi E, Gharehbaghian A, Karimi G, Samiee S, Tavasolli F, Salimi Y. Efficacy of the Confidential Unit Exclusion Option in Blood
Donors in Tehran, Iran, Determined by Using the Nucleic Acid Testing Method in 2008–2009. Hepat Mon. 2011;11(11):907-12. DOI:10.5812/kowsar.1735143X.778
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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