Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease

Sahar El-Din Bessa; Ehab Mohamed Ali; Abeer Abd El-Wahab; Sherif Nor El-Din

doi:10.5812/hepatmon.846

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Hepatitis Monthly

Home

Instructions

APC

Authors Guide Submit Manuscript

Outlines

Abstract
Copyright

https://doi.org/10.5812/hepatmon.846

Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease

Author(s):

Sahar Saad El-Din Bessa^1,*,

Ehab Mostafa Mohamed Ali²,

Abeer El-Sayed Abd El-Wahab³,

Sherif Abd El-Monem Nor El-Din²

1Department of Internal Medicine, Faculty of Medicine, Tanta University, [email protected], Egypt

2Departments of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Egypt

3Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, The Scientific Researchs City and Technology Applications, Egypt

Hepatitis Monthly:Vol. 12, issue 4; 278-285

Published online:Apr 30, 2012

Article type:Research Article

Received:Aug 07, 2011

Accepted:Feb 04, 2012

How to Cite:El-Din Bessa S, Mohamed Ali E, Abd El-Wahab A, Nor El-Din S. Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease. Hepat Mon. 2012;12(4):. doi: https://doi.org/10.5812/hepatmon.846

Abstract

Background: Chronic liver disease (CLD) is a global medical problem. This disease is associated with increased hepatic oxidative stress. One of the antioxidant enzymes that protect cells against this stress is heme oxygenase-1 (HO-1).
Objectives: This study aimed to investigate the mRNA expression of HO-1 in Egyptian patients with CLD and its relation to oxidative stress biomarkers.
Patients and Methods: Levels of serum ferritin, carboxyhemoglobin, malondialdehyde (MDA), and erythrocyte-reduced glutathione (GSH) were measured, and HO-1 mRNA expression was detected in 45 CLD patients (15 with nonalcoholic steatohepatitis [NASH], 15 with chronic hepatitis C, and 15 with liver cirrhosis) and 15 healthy controls.
Results: HO-1 mRNA expression was increased in patients with NASH, chronic hepatitis C, and liver cirrhosis compared to controls. The expression in cirrhotic patients was significantly higher than that in patients with NASH and chronic hepatitis C. Compared to controls, patients with NASH, chronic hepatitis C, and liver cirrhosis had higher levels of ferritin, carboxyhemoglobin, and MDA and lower levels of GSH. HO-1 mRNA expression was positively correlated with levels of carboxyhemoglobin, serum ferritin, and serum MDA and negatively correlated with levels of erythrocyte GSH in CLD patients.
Conclusions: HO-1 mRNA expression was significantly increased in CLD patients, and the increase reflected the severity of the disease. The significant relationship between the increased HO-1 expression and oxidative stress biomarkers in patients with CLD suggests that HO-1 may play an important role in protecting the liver from oxidative stress-dependent damage. Therefore, induction of HO-1 could be a novel therapeutic option for CLD.

Implication for health policy/practice/research/medical education:
The significant relations between the increased HO-1 expression and oxidative stress biomarkers in patients with CLD suggest that HO-1 may play an important role to protect the liver from oxidative stress-dependent damage. Reading this article is recommended to all internists and hepatologists.

Please cite this paper as:
Bessa SS, Mohamed Ali EM, Abd El-Wahab AE, Nor El-Din SA. Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease. Hepat Mon. 2012;12(4):278-85. DOI: 10.5812/hepatmon.846

Keywords

Non-alcoholic Fatty Liver Disease

Oxidative Stress

Full Text

Full text is available in PDF

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Mohammed Abdel Hamid,

Ashraf Abdel Aleem,

Ahmed Ali,

Mohammed Shatat,

Douaa Sayed,

Ali Deaf

,et al.

Abdel Hamid M, Abdel Aleem A, Ali A, Shatat M, Sayed D, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2012;12(4):. doi: https://doi.org/10.5812/hepatmon.665

30

Apr

2012

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Iman Fani,

Babak Eshrati,

Parivash Samadian,

Parisa Fani,

Yaser Gorishi,

Fatemeh Mahdaviani

,et al.

Fani I, Eshrati B, Samadian P, Fani P, Gorishi Y, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2007;7(3):. doi:

30

Apr

2012

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Nooruddin Ahamd,

Khorshed Alam,

Golam Mostafa,

Mobin Khan,

Md Alam

Ahamd N, Alam K, Mostafa G, Khan M, Alam M. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2008;8(3):. doi:

30

Apr

2012

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Reza Hosseini,

Aliakbar Pourfathollah,

Azizollah Behjati,

Hasan TorghabeH

Hosseini R, Pourfathollah A, Behjati A, TorghabeH H. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2008;8(3):. doi:

30

Apr

2012

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Rezvan Esmaeili,

Seyed Alavian,

Bashir Hajibeigi,

Elham Sabouri,

Rosita Edalat,

Ahmad Adeli

,et al.

Esmaeili R, Alavian S, Hajibeigi B, Sabouri E, Edalat R, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2009;9(3):. doi:

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 5
Last Update: 1 week ago
Scopus by Title: 18
Last Update: 1 week ago
Scopus by Title (Ref): 23
Last Update: 1 week ago
CrossRef: 15
Last Update: 3 days ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Sahar El-Din Bessa:[PubMed][Scholar]
Ehab Mohamed Ali:[PubMed][Scholar]
Abeer Abd El-Wahab:[PubMed][Scholar]
Sherif Nor El-Din:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease

Abstract

Full Text

Similar Articles

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Crossmark

Checking

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 3 days ago