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79 resultsUpdated November 01, 2026
1

Response to pioglitazone in non-alcoholic fatty liver disease patients with vs. without type 2 diabetes: A meta-analysis of randomized controlled trials

Frontiers in Endocrinology 14 (2023)

Zeyu Wang; Huiqing Du; Ying Zhao; Yadi Ren; Cuihua Ma; Hongyu Chen; Man Li; Jiageng Tian; Caihong Xue; Guangfeng Long; Meidong Xu; Yong Jiang

2

Mechanistic Insights into the Pharmacological Significance of Silymarin

Molecules 27(16) (2022)

Karan Wadhwa; Rakesh Pahwa; Manish Kumar; Shobhit Kumar; Prabodh Chander Sharma; Govind Singh; Ravinder Verma; Vineet Mittal; Inderbir Singh; Deepak Kaushik; Philippe Jeandet

3

Effects of silymarin supplementation in late pregnancy and lactation on reproductive performance, colostrum quality, blood biochemistry and inflammation levels of sows

Tropical Animal Health and Production 57(2) (2025)

Guanglei Cong; Shuangshuang Xia; Chunxue Liu; Junbo Li; Ifen Hung; Lili Zhang; Shuaipeng Guo; Bo Zhao

4

Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review

Annals of Medicine 54(1) (2022)

Alessio Aghemo; Olga P. Alekseeva; Francesco Angelico; Igor G. Bakulin; Natalia V. Bakulina; Dmitry Bordin; Alexey O. Bueverov; Oxana M. Drapkina; Anton Gillessen; Elvira M. Kagarmanova; Natalia V. Korochanskaya; U. A. Kucheryavii; Leonid B. Lazebnik; Maria A. Livzan; Igor V. Maev; Anatolii I. Martynov; Marina F. Osipenko; Evgenii I. Sas; Antonina Starodubova; Yurii P. Uspensky; Elena V. Vinnitskaya; Emilia P. Yakovenko; Alexey A. Yakovlev

5

Iron Status and Metabolic Syndrome in Patients with Non-Alcoholic Fatty Liver Disease

Middle East Journal of Digestive Diseases 8(1) (2015)

Mohammad Ebrahim Ghamarchehreh; Nematollah Jonaidi-Jafari; Mohammad Bigdeli; Hossein Khedmat; Amin Saburi

6

Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial

Clinical Nutrition ESPEN 63 (2024)

Bang-yan Li; Yue Xi; Yu-Ping Liu; Di Wang; Cheng Wang; Chao-gang Chen; Xiao-hong Fang; Zhong-xia Li; Yu-ming Chen

8

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH

Molecules 24(7) (2019)

Beatrice Anfuso; Pablo J. Giraudi; Claudio Tiribelli; Natalia Rosso

9

Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

Liver International 34(7) (2014)

Krzysztof Kurek; Dominika M. Piotrowska; Patrycja Wiesiołek‐Kurek; Bartłomiej Łukaszuk; Adrian Chabowski; Jan Górski; Małgorzata Żendzian‐Piotrowska

10

The potential of silymarin for the treatment of hepatic disorders

Clinical Phytoscience 2(1) (2017)

Claus Hellerbrand; Jörn M. Schattenberg; Philipp Peterburs; Anja Lechner; Reto Brignoli

11

Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis

Antioxidants & Redox Signaling 26(10) (2017)

Schohraya Spahis; Edgard Delvin; Jean-Michel Borys; Emile Levy

12

Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once?

Pharmaceuticals 11(4) (2018)

Matteo Tacelli; Ciro Celsa; Bianca Magro; Aurora Giannetti; Grazia Pennisi; Federica Spatola; Salvatore Petta

13

Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary‐column recycling preparative high‐performance liquid chromatography

Journal of Separation Science 37(17) (2014)

Weiquan Zhao; Guang Yang; Fanyi Zhong; Nan Yang; Xin Zhao; Yunpeng Qi; Guorong Fan

15

Hepatocellular Interactions of Potential Nutraceuticals in the Management of Inflammatory NAFLD

Cell Biochemistry and Function 42(7) (2024)

Devaraj Ezhilarasan; Kulanthaivel Langeswaran

16

An update on nonalcoholic fatty liver disease

Journal of the American Academy of Physician Assistants 27(7) (2014)

Daniel M. Provencher

17

Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway

Digestive Diseases and Sciences 63(12) (2018)

Qiang Ou; Yuanyuan Weng; Siwei Wang; Yajuan Zhao; Feng Zhang; Jianhua Zhou; Xiaolin Wu

18

State of the art

Current Opinion in Gastroenterology 30(3) (2014)

Michelle Pearlman; Rohit Loomba

19

Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways

European Journal of Pharmacology 887 (2020)

Lamiaa A. Ahmed; Maha B. Salem; Sayed H. Seif el-Din; Naglaa M. El-Lakkany; Hend O. Ahmed; Sami M. Nasr; Olfat A. Hammam; Sanaa S. Botros; Samira Saleh

20

Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis

Cochrane Database of Systematic Reviews 2021(7) (2021)

Oluyemi Komolafe; Elena Buzzetti; Audrey Linden; Lawrence MJ Best; Angela M Madden; Danielle Roberts; Thomas JG Chase; Dominic Fritche; Suzanne C Freeman; Nicola J Cooper; Alex J Sutton; Elisabeth Jane Milne; Kathy Wright; Chavdar S Pavlov; Brian R Davidson; Emmanuel Tsochatzis; Kurinchi Selvan Gurusamy

21

Efficacy of Hypoglycemic Agents in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD): A Systematic Review and Network Meta‐Analysis

Journal of Evidence-Based Medicine 18(2) (2025)

Qiao Ren; Yao Tan; Guixiang Zhang; Yuzhao Dai; Lidan Yang; Yunmo Wu; He He; Jie Chen

22

Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism

Expert Review of Gastroenterology & Hepatology 8(4) (2014)

Samir Rouabhia; Natasa Milic; Ludovico Abenavoli

23

Pharmacological interventions for non-alcohol related fatty liver disease (NAFLD)

Cochrane Database of Systematic Reviews 2017(4) (2017)

Rosa Lombardi; Simona Onali; Douglas Thorburn; Brian R Davidson; Kurinchi Selvan Gurusamy; Emmanuel Tsochatzis

24

Comparison of efficacy of anti-diabetics on non-diabetic NAFLD: A network meta-analysis

Frontiers in Pharmacology 13 (2023)

Dachuan Jin; Zhongfeng Cui; Shunqin Jin; Tao Zhou; Baoqiang Guo; Peng Gao; Guangming Li

25

Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review

Cureus (2023)

Ernesto Calderon Martinez; Domenica Herrera; Saruveish Mogan; Zainab Hameed; Ayesha Altaf Jangda; Tayyaba J Khan; Palvi Mroke; Samar Sajid; Yash R Shah; Imran Baig

26

Har silibinin en plass i behandlingen av leversykdommer?

Tidsskrift for Den norske legeforening 134(4) (2014)

Gülen Arslan Lied; Odd Helge Gilja; Trygve Hausken

28

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Scientia Pharmaceutica 91(4) (2023)

Saverio Nucera; Rosa Maria Bulotta; Stefano Ruga; Rosamaria Caminiti; Maria Serra; Roberto Bava; Fabio Castagna; Carmine Lupia; Mariangela Marrelli; Filomena Conforti; Giancarlo Statti; Vincenzo Mollace; Ernesto Palma

29

Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice

Drug Design, Development and Therapy Volume 15 (2021)

Xin Zhao; Haoxiang Wang; Yue Yang; Yuting Gou; Zhiying Wang; Dingyi Yang; Chong Li

30

Silymarin for Treating Toxic Liver Disease: International Consensus Recommendations

Gastro Hep Advances 1(5) (2022)

Anton Gillessen; Francesco Angelico; Jun Chen; Lungen Lu; Maria Isabel Lucena; Qingchun Fu; Qing Xie; Raul J. Andrade; Wen Xie; Xiaoyuan Xu; Yanyan Yu; Yi-min Mao; Yuemin Nan

31

Expert Opinion on the Management of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Middle East with a Focus on the Use of Silymarin

Gastroenterology Insights 12(2) (2021)

Ahmed Hashem; Yogesh Shastri; Malfi Al Otaibi; Elwin Buchel; Hussam Saleh; Reyaz Ahmad; Hamouda Ahmed; Fateh Al Idris; Saleh Ahmed; Mohamed Guda; Anton Gillessen

32

Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis

World Journal of Gastroenterology 23(27) (2017)

Camila Ribeiro de Avelar; Emile Miranda Pereira; Priscila Ribas de Farias Costa; Rosângela Passos de Jesus; Lucivalda Pereira Magalhães de Oliveira

33

Comparison of fenofibrate and pioglitazone effects on patients with nonalcoholic fatty liver disease

European Journal of Gastroenterology & Hepatology 29(12) (2017)

Malek Yaghoubi; Sattar Jafari; Behnam Sajedi; Sepehr Gohari; Samira Akbarieh; Amir H. Heydari; Maryam Jameshoorani

35

Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD

Annals of Hepatology 14(1) (2015)

Hong Ma; Guo-Ping You; Fan Cui; Lu-Fang Chen; Xiang-Jiu Yang; Li-Gang Chen; Hua-Dong Lu; Wen-Qiang Zhang

36

Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

BMC Complementary Medicine and Therapies 21(1) (2021)

Tewodros Mengesha; Natesan Gnanasekaran; Tsegaye Mehare

37

Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury

BMC Complementary Medicine and Therapies 25(1) (2025)

Kasra Shahsavari; Shireen Shams Ardekani; Mohammad Reza Shams Ardekani; Majid Mokaber Esfahani; Hossein Kazemizadeh; Tannaz Jamialahmadi; Mehrdad Iranshahi; Mahnaz Khanavi; Maede Hasanpour

39

The Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 2: Management and special groups

Journal of Gastroenterology and Hepatology 33(1) (2018)

Shiv Chitturi; Vincent Wai‐Sun Wong; Wah‐Kheong Chan; Grace Lai‐Hung Wong; Simon Kin‐Hung Wong; Jose Sollano; Yen‐Hsuan Ni; Chun‐Jen Liu; Yu‐Cheng Lin; Laurentius Adrianto Lesmana; Seung Up Kim; Etsuko Hashimoto; Masahide Hamaguchi; Khean‐Lee Goh; Jiangao Fan; Ajay Duseja; Yock Young Dan; Yogesh Chawla; Geoff Farrell; Henry Lik‐Yuen Chan

41

Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

Clinical and Molecular Hepatology 28(3) (2022)

Han Ah Lee; Young Chang; Pil Soo Sung; Eileen L. Yoon; Hye Won Lee; Jeong-Ju Yoo; Young-Sun Lee; Jihyun An; Do Seon Song; Young Youn Cho; Seung Up Kim; Yoon Jun Kim

42

The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review

European Journal of Clinical Pharmacology 80(1) (2024)

Maria Zachou; Pagona Flevari; Narjes Nasiri-Ansari; Constantinos Varytimiadis; Evangelos Kalaitzakis; Eva Kassi; Theodoros Androutsakos

43

Effects of silymarin on metabolic syndrome: a review

Journal of the Science of Food and Agriculture 98(13) (2018)

Maryam Vahabzadeh; Nafise Amiri; Gholamreza Karimi

44

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

Best Practice & Research Clinical Gastroenterology 28(4) (2014)

Peter Dietrich; Claus Hellerbrand

45

Effectiveness of drug interventions in nonalcoholic fatty liver disease: A network meta-analysis

World Journal of Diabetes 12(9) (2021)

Yi-Zhou Huang; Gang-Yi Yang; Cong Wang; Xing-Yu Chen; Li-Li Zhang

46

Lactobacillus rhamnosus GG Combined with Metformin Alleviates Alcohol-Induced Liver Inflammation in Mice by Maintaining the Intestinal Barrier and Regulating Treg/Th1 Cells

Journal of Medicinal Food 28(4) (2025)

Yin Zhu; Yizhi Pan; Xiaozhi Wang; Li Wei; Lujian Zhu; Yu Guo; HaoRan Jin; Yingying Gu; Yaqin Wang; Yongping Chen; Lanman Xu

47

Sodium-glucose cotransporter protein-2 inhibitors and glucagon-like peptide-1 receptor agonists versus thiazolidinediones for non-alcoholic fatty liver disease: A network meta-analysis

Acta Diabetologica 59(4) (2022)

Chen Ding; Yaxin Tang; Wenqiang Zhu; Piaopiao Huang; Pingan Lian; Juanli Ran; Xiansheng Huang

48

Sylimarin: Traditional and New Effects

Рецепт(1) (2021)

Н.Н. Силивончик; Т.Н. Якубчик

49

Comparative Efficacy of Herbal Products on Metabolic Parameters in Metabolic Dysfunction–Associated Liver Disease: A Systematic Review and Network Meta-Analysis

Gastro Hep Advances 5(10) (2026)

Revathi Thirumushi Sairaj; Alejandro Chen Liang; Yeison Cruz Castillo; Mariela Denise Fermin Madera; Jose Medina; Tatiana Alexandra Moreno Díaz; Gabriela Flores Monar; Supritha Chintamaneni; Camila Sanchez Cruz; Rashmi Advani; Sushovan Guha; Ernesto Calderón-Martinez

50

Clinical efficacy of Silybum marianum seed extract in treatment of type 2 diabetes mellitus and non-alcoholic fatty liver disease: a narrative review

Journal of Medicinal Plants 1(73) (2020)

Sayed Mohammad Mohammadi; Saeed kianbakht; Shamsali Rezazadeh; Mojtaba Ziaee; Hasan Fallah Huseini

51

Non-Alcoholic Fatty Liver Disease (NAFLD): The Search for a Cure

European Medical Journal (2016)

Alabagi Abdulla; Charity Reynolds; H Hesham A-Kader

55

Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

World Journal of Gastroenterology 20(34) (2014)

Kareem Hassan

56

The Effectiveness of Pentoxifylline in NAFLD: A Meta-Analysis

Philippine Journal of Internal Medicine 57(4) (2019)

John Mark K Torres; Carlos Rolando Cuaño; Janus P Ong

57

Non-alcoholic fatty liver disease: need for a balanced nutritional source

British Journal of Nutrition 112(11) (2014)

Jayagopalan Veena; Anjaneyulu Muragundla; Srinivas Sidgiddi; Swaminathan Subramaniam

58

Metformin and Probiotics Interplay in Amelioration of Ethanol‐Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury

Mediators of Inflammation 2021(1) (2021)

Farhin Patel; Kirti Parwani; Dhara Patel; Palash Mandal; Muthuraju Sangu

59

Association of Serum Ferritin and Inflammatory Biomarkers with Insulin Resistance in Chinese Type 2 Diabetes Mellitus Patients

Journal of Biomedical Research & Environmental Sciences 1(7) (2020)

P Paudel; S Zhang; B Guo; A Pannu; G Rasalingam; R Sah; B Desai; A Yin; C Gu; Y Yuan; L Chen; W Niu

60

Benefits of Combining Sonchus brachyotus DC. Extracts and Synbiotics in Alleviating Non-Alcoholic Fatty Liver Disease

Foods 12(18) (2023)

Wenwu Huang; Boyuan Shen; Xiumei Li; Tongcun Zhang; Xiang Zhou

61

Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Randomized, Double-Blinded, Double-Simulated Multicenter Study

Journal of Diabetes Research 2023 (2023)

Fu Jianfang; Xiao Wanxia; Gao Xiling; Xu Jing; Yang Wenjuan; Liu Jianrong; He Qingzhen; Ma Kaiyan; Lian Jingxuan; Chen Taixiong; Xu Qian; Li Mengying; Ming Jie; Ji Qiuhe; Ferdinando Carlo Sasso

62

Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease

Clinics in Liver Disease 20(2) (2016)

Swaytha Ganesh; Vinod K. Rustgi

64

Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD

Diseases 6(3) (2018)

Brandon J. Perumpail; Andrew A. Li; Umair Iqbal; Sandy Sallam; Neha D. Shah; Waiyee Kwong; George Cholankeril; Donghee Kim; Aijaz Ahmed

65

Comparative Efficacy of Herbal Products for Improving Liver Enzymes and Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Network Meta-Analysis

Gastro Hep Advances 5(9) (2026)

Alejandro Chen Liang; Yeison Cruz Castillo; Mariela Denise Fermin Madera; Revathi Thirumushi Sairaj; Jose Medina; Tatiana Alexandra Moreno Díaz; Supritha Chintamaneni; Gabriela Flores Monar; Camila Sanchez Cruz; Rashmi Advani; Sushovan Guha; Ernesto Calderón-Martinez

66

Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials

Diabetes Research and Clinical Practice 220 (2025)

Shao Yin; Fengya Zhu; Ying Liu; Qiu Chen

67

Future therapy for non‐alcoholic fatty liver disease

Liver International 38(S1) (2018)

Danny Issa; Vaishali Patel; Arun J. Sanyal

68

Silymarin Modulates Microbiota in the Gut to Improve the Health of Sow from Late Gestation to Lactation

Animals 12(17) (2022)

Shengyu Xu; Xiaojun Jiang; Xinlin Jia; Xuemei Jiang; Lianqiang Che; Yan Lin; Yong Zhuo; Bin Feng; Zhengfeng Fang; Jian Li; Jianping Wang; Zhihua Ren; De Wu

69

A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis

Clinical Gastroenterology and Hepatology 15(12) (2017)

Chan Wah Kheong; Nik Raihan Nik Mustapha; Sanjiv Mahadeva

70

Effects of different natural products in patients with non‐alcoholic fatty liver disease—A network meta‐analysis of randomized controlled trials

Phytotherapy Research 38(7) (2024)

Hongshuai Liu; Yufei Li; Yan Jin; Xin Li; Dongxian Wang; Xiaowen Yu; Zhenyuan Jiang; Guoliang Yin; Suwen Chen; Xin Zhang; Decheng Meng; Wenfei Yu; Wenyin Jiang; Fengxia Zhang

71

The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease

Medicine 96(49) (2017)

Sheng Zhong; Yuxiang Fan; Qi Yan; Xingyu Fan; Bo Wu; Yujuan Han; Ying Zhang; Yong Chen; Huimao Zhang; Junqi Niu

72

Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries

Hypertension Research 45(12) (2022)

Xin Wen; Yidi Peng; Bohao Zheng; Shaying Yang; Jing Han; Fan Yu; Tingting Zhou; Li Geng; Zhiming Yu; Lei Feng

73

Sirt1 and Sirt6 Mediate Beneficial Effects of Rosiglitazone on Hepatic Lipid Accumulation

PLoS ONE 9(8) (2014)

Soo Jin Yang; Jung Mook Choi; Eugene Chang; Sung Woo Park; Cheol-Young Park; Aimin Xu

74

Temporal Relationship between Diet-Induced Steatosis and Onset of Insulin/Leptin Resistance in Male Wistar Rats

PLOS ONE 10(2) (2015)

Li Zhang; Haiyan Song; Yingli Ge; Guang Ji; Zemin Yao; Julie A. Chowen

75

Silymarin suppresses HepG2 hepatocarcinoma cell progression through downregulation of Slit-2/Robo-1 pathway

Pharmacological Reports 72(1) (2020)

Nuriye Ezgi Bektur Aykanat; Sedat Kacar; Serife Karakaya; Varol Sahinturk

76

Silymarin for adults with metabolic dysfunction-associated steatotic liver disease

Cochrane Database of Systematic Reviews 2025(6) (2025)

Caie Wang; Yiyang Shang; Ghid Kanaan; Lu Chai; Hui Li; Xingshun Qi

78

Effect of Medicinal Plants and Natural Products on Liver Enzymes in Non-alcoholic Fatty Liver Patients in Iran: A Systematic Review and Meta-Analysis

International Journal of Preventive Medicine 13(1) (2022)

Moloud Fakhri; Hafez Fakheri; Mohammad Azadbakht; Mahmood Moosazadeh; Seyde Sedighe Yousefi

79

Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

Annual Review of Pharmacology and Toxicology 56(1) (2016)

Swetha Rudraiah; Xi Zhang; Li Wang