Hepatitis Monthly
Forough Saki4, 
Zohreh Karamizadeh1,*, Naser Honar2, Hossein Moravej3, Soheil Ashkani-Esfahani4, Mohammad Hossein Namvar Shooshtarian5The prevalence of obesity and its related comorbidities, such as fatty liver, in children is increasing worldwide mostly due to changes in diet and life-style. Many serological markers have been suggested for screening of fatty liver but investigations for finding more reliable factors are still in progress.
This study aimed to investigate the correlation between the level of retinol binding protein-4 (RBP4) in the serum and sonographic grading of fatty-liver severity in obese Iranian children.
This case-control, double-blind study involved 51 obese children aged between five and 17 years as the case group. In addition, 35 healthy lean children with no liver problems were selected as the control group. Plasma RBP4 (using an ELISA), serum triglycerides (TG), low-density-lipoproteins (LDL), high-density-lipoproteins (HDL), total-cholesterol (Chol), and body mass index (BMI) were measured. Grading the severity of the fatty liver condition was done by an expert radiologist in the case group.
RBP4 levels in obese children (19 482.9 3 302.2 pg/ml) were higher than those found in the lean control group (14 295.68 2 381.3 pg/ml) (P < 0.05). In the obese patients, RBP4 levels showed a significant correlation with the grade of fatty liver and BMI (P < 0.05).
It was found that the level of RBP4 had a strong correlation with the severity of fatty liver. Therefore, RBP4 may be considered as a useful, noninvasive predictive biomarker of intrahepatic lipid content in obese children prior to using radiological investigations. In particular, abdominal sonography, for the evaluation of intrahepatic lipid content in obese patients, as the sensitivity of a sonography is decreased due to the increased thickness of the abdominal wall as a result of fat deposits.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Karamizadeh Z, Saki F, Ashkani-Esfahani S. Investigation of the Relationship Between Retinol Binding Protein 4, Metabolic Syndrome and Insulin Resistance in Iranian Obese 5-17 Year Old Children. Inn J Pediatr. 2013;23(4):. doi:
Kazemi SA, Kamali K, Asgari L, Eftekhari K. Assessment of the Relationship Between Prevalence of Reporting Fatty Liver Disease by Ultrasound and Body Mass Index in Children. Inn J Pediatr. 2017;27(1):e8028. doi: https://doi.org/10.5812/ijp.8028
Avazpour A, Bahramnejad M, Hassani AH, Matin S, Moatamedi M. Non-alcoholic Fatty Liver Disease in Overweight and Obese Children; Can Ultrasonography Substitute Laboratory Studies? A Case-Control Study. Inn J Pediatr. 2024;34(5):e148096. doi: https://doi.org/10.5812/ijp-148096
Imanzadeh F, Olang B, Sayyari AA, Dara N, Khatami K, et al. Prevalence and Related Factors for Non-alcoholic Fatty Liver Disease in Obese Students. J Compr Ped. 2023;14(3):e135095. doi: https://doi.org/10.5812/compreped-135095
Gheibi S, Maleki F, Safiri S, Esmaeili GouvarchinGhaleh H, Mansouri Motlagh B, et al. Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Obese and Overweight Children in the Northwest of Iran. Hepat Mon. 2019;19(10):e92199. doi: https://doi.org/10.5812/hepatmon.92199
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