Full Text
Full text is available in PDF
Background:
Liver enzymes elevations (LEE) can be observed after kidney transplantation due to multifactorial causes.
Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Non-Viral Related Liver Enzymes Elevation After Kidney Transplantation
Authors
1Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3Middle East Liver Diseases Center (MELD), Tehran, IR Iran
*Corresponding Author: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran. Tel/Fax: +98-2188934125, einollahi@numonthly.com. Email: einollahi@numonthly.com
Published online:Feb 04, 2014
Article type:Research Article
Received:Nov 06, 2012
Accepted:Sep 30, 2013
How to Cite:Einollahi B, Ghadian A, Ghamar-Chehreh E, Alavian SM. Non-Viral Related Liver Enzymes Elevation After Kidney Transplantation. Hepat Mon. 2014;14(2):9036. doi: https://doi.org/10.5812/hepatmon.9036
Abstract
Objectives:
We performed a retrospective study on 1589 kidney transplants, 971 male and 618 female, who were hepatitis B surface antigen (HBsAg) and hepatitis C virus-antibody (HCV Ab) negative, and had no other liver diseases, to detect the prevalence of LEE and its risk factors in these patients between May 2008 and May 2010.
Patients and methods:
Liver enzymes and other biochemical parameters were measured in all recipients. Patients were divided into three groups, according to laboratory test time since transplantation: Group I, less than 3 months, Group II, 4 - 12 months after transplantation, and Group III, more than one year post-transplantation.
Results:
The highest LEE was more frequent in older patients (P < 0.001) and male individuals (P < 0.001). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in patients who received kidneys from deceased donors (10.4% and 23.8%, respectively) as compared to living donor transplants (5.6% and 14.8%, respectively) (P < 0.001). The elevation of ALT was the liver enzyme abnormality after kidney transplantation with the highest prevalence (34.3%). The levels of ALT and AST were significantly elevated within the first 3 months after transplantation, followed by the 4-12 months period (P < 0.001). There was a reverse correlation between liver enzyme levels and renal allograft function in both univariate and linear regression analyses. This correlation increased over time. There was also a significant relation between cyclosporine blood levels and liver enzyme values in the univariate analysis. However, this relationship was attenuated over time. Elevated liver enzymes also correlated with anemia.
Conclusions:
The LEE is a common finding among kidney transplant recipients. Serial monitoring of aminotransferases, particularly ALT, should be performed in all patients after kidney transplantation.
Highlights
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
8
Oct
2016
Transplantation of Deceased Donor Livers With Elevated Levels of Serum Transaminases at Shiraz Transplant Center
Nasir Fakhar,
Saman Nikeghbalian,
Kourosh Kazemi,
Ali Reza Shamsayeefar,
Siavash Gholami,
Amir Kasraianfard
,et al.Fakhar N, Nikeghbalian S, Kazemi K, Shamsayeefar AR, Gholami S, et al. Transplantation of Deceased Donor Livers With Elevated Levels of Serum Transaminases at Shiraz Transplant Center. Hepat Mon. 2016;16(10):e40140. doi: https://doi.org/10.5812/hepatmon.40140
16
Nov
2020
Evaluation of Liver Enzymes in End-Stage Renal Disease Patients on the Renal Transplant-Waiting List in North-West of Iran
Samaneh Sabouri,
Monavar Afzal Aghaee,
Zahra Lotfi,
Habibollah Esmaily,
Maryam Alizadeh,
Hooman Mosannen Mozafari
Sabouri S, Afzal Aghaee M, Lotfi Z, Esmaily H, Alizadeh M, et al. Evaluation of Liver Enzymes in End-Stage Renal Disease Patients on the Renal Transplant-Waiting List in North-West of Iran. Nephro-Urol Mon. 2020;12(4):e107859. doi: https://doi.org/10.5812/numonthly.107859
27
Jul
2025
Latent Tuberculosis Management in Liver Transplant Recipients: Insights from a Retrospective Analysis
Mohsen Aliakbarian,
Mahboobeh Ghasemzadeh Rahbardar,
Zeinab Barzegar Torghabeh,
Gholamhossein Faghani,
Rozita Khodashahi
Aliakbarian M, Ghasemzadeh Rahbardar M, Barzegar Torghabeh Z, Faghani G, Khodashahi R. Latent Tuberculosis Management in Liver Transplant Recipients: Insights from a Retrospective Analysis. Arch Clin Infect Dis. 2025;20(5):e158129. doi: https://doi.org/10.5812/archcid-158129
13
Jun
2013
Dyslipidemia After Kidney Transplantation and Correlation With Cyclosporine Level
Mahboobeh-Sadat Hosseini,
Zohreh Rostami,
Behzad Einollahi
Hosseini M, Rostami Z, Einollahi B. Dyslipidemia After Kidney Transplantation and Correlation With Cyclosporine Level. Nephro-Urol Mon. 2013;5(3):. doi: https://doi.org/10.5812/numonthly.11890
1
Feb
2014
Upper Limits of Normal Aminotransferases in Children of Southern Iran
Seyed Mohsen Dehghani,
Asma Erjaee,
Mahmood Haghighat,
Mohammad Hadi Imanieh,
Razieh Ahmadi
Dehghani SM, Erjaee A, Haghighat M, Imanieh MH, Ahmadi R. Upper Limits of Normal Aminotransferases in Children of Southern Iran. J Compr Ped. 2014;5(1):15274. doi: https://doi.org/10.17795/compreped-15274
Cited by
- Scopus by DOI: 8
Last Update: 1 week ago
- Scopus by Title: 8
Last Update: 1 week ago
- Scopus by Title (Ref): 8
Last Update: 1 week ago
- CrossRef: 7
Last Update: 3 hours ago
- OpenAlex: 11
Last Update: 8 hours ago
- OpenCitations: 7
Last Update: 5 days ago
Comments
Number of Comments:0