Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients

Reza Ghanbari; Mehrdad Ravanshad; Seyed Hosseini; Ramin Yaghobi; Kiana Shahzamani

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Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients

Author(s):

Reza Ghanbari¹,

Mehrdad Ravanshad

^2,*,

Seyed Younes Hosseini¹,

Ramin Yaghobi³,

Kiana Shahzamani¹

1Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR.Iran

2Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, ravanshad@modares.ac.ir, Tehran, IR.Iran

3Department of Virology, Shiraz Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, IR.Iran

Hepatitis Monthly:Vol. 10, issue 2; 80-87

Published online:Jun 30, 2010

Article type:Research Article

Received:Jul 02, 2009

Accepted:Feb 18, 2010

How to Cite:Ghanbari R, Ravanshad M, Hosseini S Y, Yaghobi R, Shahzamani K. Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients.Hepat Mon.2010;10(2):80-87.

Abstract

Background and Aims: Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified member of the Flaviviridae family. Its clinical significance in chronic hepatitis C infection remains controversial. There is a geographical difference in the distribution of GBV-C in the world. The frequency of GBV-C infection among hepatitis C virus (HCV) infected patients varies. The aim of the current study was to determine the prevalence and genotypes of GBV-C among Iranian patients infected with chronic HCV.

Methods: Infection with GBV-C was surveyed in 71 chronic confirmed hepatitis C infected patients. These samples were collected at the Digestive Disease Research Center (DDRC) of Shariati Hospital, Tehran, Iran from January to October 2007. The 5’-UTR region of GBV-C RNA was detected using a novel in-house touchdown nested reverse transcription polymerase chain reaction (RT-PCR), the products were sequenced and the results were aligned and phylogenically analyzed.

Results: Of the 71 HCV-infected patients, 31 (43.6%) were found positive for GBV-C RNA. Sequencing and phylogenic analysis showed that the samples were Genotype 2 of GBV-C.

Conclusions: It seems that there is a high rate of GBV-C infection among Iranian patients infected with chronic HCV. In comparison with the six reference genotypes, it was observed that all the samples were categorized in Genotype 2 of GBV-C, prevalent in North America, Africa and in European countries.

Keywords: GBV-C, HCV, Prevalence, Genotyping, Iranian, 5’-UTR

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Author(s):

Reza Ghanbari:[PubMed][Scholar]
Mehrdad Ravanshad:[PubMed][Scholar]
Seyed Hosseini:[PubMed][Scholar]
Ramin Yaghobi:[PubMed][Scholar]
Kiana Shahzamani:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients

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