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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients
Authors
1Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR.Iran
2Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, ravanshad@modares.ac.ir, Tehran, IR.Iran
3Department of Virology, Shiraz Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, IR.Iran
*Corresponding Author: Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, ravanshad@modares.ac.ir, Tehran, IR.Iran. Tel: +98 21 8288 3836. Fax: +98 21 8288 3836. Email: ravanshad@modares.ac.ir
Published online:Jun 30, 2010
Article type:Research Article
Received:Jul 02, 2009
Accepted:Feb 18, 2010
How to Cite:Ghanbari R, Ravanshad M, Hosseini S, Yaghobi R, Shahzamani K. Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients. Hepat Mon. 2010;10(2):. doi:
Abstract
Background and Aims: Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified member of the Flaviviridae family. Its clinical significance in chronic hepatitis C infection remains controversial. There is a geographical difference in the distribution of GBV-C in the world. The frequency of GBV-C infection among hepatitis C virus (HCV) infected patients varies. The aim of the current study was to determine the prevalence and genotypes of GBV-C among Iranian patients infected with chronic HCV.
Methods: Infection with GBV-C was surveyed in 71 chronic confirmed hepatitis C infected patients. These samples were collected at the Digestive Disease Research Center (DDRC) of Shariati Hospital, Tehran, Iran from January to October 2007. The 5’-UTR region of GBV-C RNA was detected using a novel in-house touchdown nested reverse transcription polymerase chain reaction (RT-PCR), the products were sequenced and the results were aligned and phylogenically analyzed.
Results: Of the 71 HCV-infected patients, 31 (43.6%) were found positive for GBV-C RNA. Sequencing and phylogenic analysis showed that the samples were Genotype 2 of GBV-C.
Conclusions: It seems that there is a high rate of GBV-C infection among Iranian patients infected with chronic HCV. In comparison with the six reference genotypes, it was observed that all the samples were categorized in Genotype 2 of GBV-C, prevalent in North America, Africa and in European countries.
Keywords: GBV-C, HCV, Prevalence, Genotyping, Iranian, 5’-UTR
Highlights
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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