Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Zary Nokhodian; Mohammad Yazdani; Majid Yaran; Parisa Shoaei; Mina Mirian; Behrooz Ataei Infectious Diseases Research Center, Isfahan University of Medical Sciences; Anahita Babak; Mehdi Ataie; Zary Nokhodian

doi:10.5812/hepatmon.6144

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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https://doi.org/10.5812/hepatmon.6144

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Author(s):

Zary Nokhodian,

Mohammad Yazdani,

Majid Yaran,

Parisa Shoaei,

Mina Mirian,

Behrooz Ataei Infectious Diseases Research Center, Isfahan University of Medical Sciences,

Anahita Babak,

Mehdi Ataie,

Zary Nokhodian^1,*

1Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran

Hepatitis Monthly:Vol. 12, issue 7; 253-258

Published online:Apr 30, 2012

Article type:Research Article

Received:Jan 28, 2011

Accepted:Mar 14, 2011

How to Cite:Nokhodian Z, Yazdani M, Yaran M, Shoaei P, Mirian M, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2012;12(7):. doi: https://doi.org/10.5812/hepatmon.6144

Abstract

Background: While prevalence of Hepatitis B virus (HBV) in patients with end-stage renal failure (ESRF) who are undergoing dialysis has decreased significantly during the past few decades, it still remains a distinct clinical problem. The immunosuppressive nature of renal disease often leads to chronicity of the HBV infection and an opportunity for nosocomial spread of the infection among dialysis patients. Egypt is among the countries with intermediate endemicity of HBsAg (range, 2%–7%). Large-scale geographic heterogeneity in HBV prevalence has been reported worldwide and HBV prevalence is especially heterogeneous in Egypt.
Objectives: To assess the prevalence of occult HBV infection (OBI) in hemodialysis patients with or without chronic hepatitis C (HCV) from Minia and Assuit, Upper Egypt, using HBV DNA assays.
Patient and Methods: Sera from 145 hemodialysis patients with negative HbsAg were investigated for HBV DNA using real-time polymerase chain reaction (RT-PCR). Only serum samples with repeatedly detectable HBV DNA were considered positive. Patients were divided into 2 groups: HCV RNA positive and HCV RNA negative, based on the results of a third generation enzyme linked immunosorbent assay (ELISA) anti-HCV test and HCV RNA PCR.
Results: HBV DNA was detected in 6 of the 145 patients (4.1%) and HBcAb was detected in 29/145 patients (20%). There were no statistically significant differences in the age, duration of hemodialysis, biochemical parameters, serological markers of HBV, or HBV DNA between patients with and without HCV infection.
Conclusions: Four percent of the hemodialysis patients had OBI. There was no significant difference in the prevalence of OBI between hemodialysis patients with or without HCV co-infection.

Implication for health policy/practice/research/medical education:
Exploring the prevalence of occult HBV infection in hemodialysis patients with or without chronic hepatitis C in Egypt has significant clinical implication. Reading this article is recommended to all internists, gastroenterologists and hepatologists.

Please cite this paper as:
Abu El Makarem MA, Abdel Hamid M, Abdel Aleem A, Ali A, Shatat M, Sayed D, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2012;12(4):253-8. DOI: 10.5812/hepatmon.665

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Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Mohammed Abdel Hamid,

Ashraf Abdel Aleem,

Ahmed Ali,

Mohammed Shatat,

Douaa Sayed,

Ali Deaf

,et al.

Abdel Hamid M, Abdel Aleem A, Ali A, Shatat M, Sayed D, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2012;12(4):. doi: https://doi.org/10.5812/hepatmon.665

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Fani I, Eshrati B, Samadian P, Fani P, Gorishi Y, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2007;7(3):. doi:

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Md Alam

Ahamd N, Alam K, Mostafa G, Khan M, Alam M. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2008;8(3):. doi:

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Hosseini R, Pourfathollah A, Behjati A, TorghabeH H. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2008;8(3):. doi:

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Rosita Edalat,

Ahmad Adeli

,et al.

Esmaeili R, Alavian S, Hajibeigi B, Sabouri E, Edalat R, et al. Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection. Hepat Mon. 2009;9(3):. doi:

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Author(s):

Zary Nokhodian:[PubMed][Scholar]
Mohammad Yazdani:[PubMed][Scholar]
Majid Yaran:[PubMed][Scholar]
Parisa Shoaei:[PubMed][Scholar]
Mina Mirian:[PubMed][Scholar]
Behrooz Ataei Infectious Diseases Research Center, Isfahan University of Medical Sciences:[PubMed][Scholar]
Anahita Babak:[PubMed][Scholar]
Mehdi Ataie:[PubMed][Scholar]
Zary Nokhodian:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

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