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41 resultsUpdated October 23, 2026
1

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action

Biochemical Pharmacology 183 (2020)

Hassan Yousefi; Ladan Mashouri; Samuel C. Okpechi; Nikhilesh V. Alahari; Suresh K. Alahari

2

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

Journal of pharmacopuncture 24(1) (2021)

Zahra Ahmadi; Reza Mohammadinejad; Sahar Roomiani; Elham Ghasemipour Afshar; Milad Ashrafizadeh

3

Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway

Life Sciences 256 (2020)

Fatma M. Amin; Rania Ramadan Abdelaziz; Mohamed F. Hamed; Manar A. Nader; George S.G. Shehatou

5

Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson’s disease: Possible involvement of PI3K/ERβ signaling

European Journal of Pharmacology 801 (2017)

Tourandokht Baluchnejadmojarad; Nida Jamali-Raeufy; Sedigheh Zabihnejad; Nafiseh Rabiee; Mehrdad Roghani

6

Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium

Biomedicine & Pharmacotherapy 102 (2018)

Moslem Najafi; Elham Noroozi; Aniseh Javadi; Reza Badalzadeh

7

Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats

Cellular Physiology and Biochemistry 44(5) (2017)

Liliang Shu; Wanzhe Zhang; Chen Huang; Gongcheng Huang; Gang Su

8

Phosphorylation of GSK-3β and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium

European Journal of Pharmacology 765 (2015)

Behnaz Mokhtari; Reza Badalzadeh; Alireza Alihemmati; Mustafa Mohammadi

9

Troxerutin Preconditioning and Ischemic Postconditioning Modulate Inflammatory Response after Myocardial Ischemia/Reperfusion Injury in Rat Model

Inflammation 40(1) (2016)

Reza Badalzadeh; Behzad Baradaran; Alireza Alihemmati; Bahman Yousefi; Azam Abbaszadeh

10

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Acta Physiologica Hungarica 102(4) (2015)

Roya Naderi; Gisou Mohaddes; M Mohammadi; Alireza Alihemmati; Reza Badalzadeh; Rana Ghaznavi; Rafighe Ghiasi; Sh. Mohammadi

11

Treatment with troxerutin protects against cisplatin-induced kidney injury in mice

Acta chirurgica Belgica 119(1) (2018)

Fereshteh Dehnamaki; Akbar Karimi; Ali Asghar Pilehvarian; Iman Fatemi; Elham Hakimizadeh; Ayat Kaeidi; Mohammad Allahtavakoli; Amir M. Rahmani; Morteza Khademalhosseini; Gholamreza Bazmandegan

13

Effect of the administration of Solanum nigrum fruit on prevention of diabetic nephropathy in streptozotocin-induced diabetic rats

Pharmacognosy Research 9(4) (2017)

Nepton Soltani; Fariba Azarkish; Kobra Hashemi; Ardashir Talebi; Mohammad Kamalinejad; Nima Pouladian

14

Effect of troxerutin on oxidative stress and expression of genes regulating mitochondrial biogenesis in doxorubicin-induced myocardial injury in rats

Naunyn-Schmiedeberg s Archives of Pharmacology 393(7) (2020)

Sara Babaei-Kouchaki; Vahab Babapour; Negar Panahi; Reza Badalzadeh

15

Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis.

PubMed 9(4) (2019)

Afsaneh Qadiri; Fariba Mirzaei; Gholamreza Hamidian; Zohreh Zavvari Oskuye; Mahdi Ahmadi; Hajar Oghbaei; Keyvan Mehri; Amir Mansour Vatankhah; ‬Rana Keyhanmanesh

16

Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway

Pharmaceuticals 13(1) (2020)

João Antônio Leal de Miranda; Conceição da Silva Martins; Lázaro de Sousa Fideles; Maria Lucianny Lima Barbosa; João Erivan Façanha Barreto; Helder Bindá Pimenta; Francisco Orlando Rafael Freitas; Paulo Vitor de Souza Pimentel; Cláudio Silva Teixeira; Ariel Gustavo Scafuri; Maria Cláudia dos Santos Luciano; Joabe Lima Araújo; Jefferson Almeida Rocha; Ícaro Gusmão Pinto Vieira; Nágila Maria Pontes Silva Ricardo; Matheus da Silva Campelo; Maria Elenir Nobre Pinho Ribeiro; Gerly Anne de Castro Brito; Gilberto Santos Cerqueira

17

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

Molecules 20(12) (2015)

Irina Camelia Chiş; Andrei Coseriu; Ramona Simedrea; Adrian Oros; Andras Laszlo Nagy; Simona Valeria Clichici

18

Troxerutin attenuates diet‐induced oxidative stress, impairment of mitochondrial biogenesis and respiratory chain complexes in mice heart

Clinical and Experimental Pharmacology and Physiology 44(1) (2016)

Rajagopalan Geetha; Sathiya Priya Chandrasekaran; Carani Venkatraman Anuradha

19

Antifatigue effects of troxerutin on exercise endurance capacity, oxidative stress and matrix metalloproteinase‐9 levels in trained male rats

Fundamental and Clinical Pharmacology 31(4) (2017)

Mohammad Yasin Zamanian; Mohammad Reza Hajizadeh; Ali Esmaeili Nadimi; Ali Shamsizadeh; Mohammad Allahtavakoli

20

Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats.

PubMed 22(2) (2019)

Zohreh Zavvari Oskuye; Fariba Mirzaei; Gholamreza Hamidian; Keyvan Mehri; Afsaneh Qadiri; Mahdi Ahmadi; Hajar Oghbaei; Amir Mansour Vatankhah; ‬Rana Keyhanmanesh

21

Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring.

PubMed 21(7) (2018)

Roghayeh Diba; Gisou Mohaddes; Fariba Mirzaie Bavil; Fereshteh Farajdokht; Parvin Bayandor; Maryam Hosseindoost; Keyvan Mehri; Zohreh Zavvari Oskuye; Shirin Babri

22

Protective effect of ghrelin on testicular damages caused by chronic hypoxia in rats: A histopathological study

Andrologia 50(4) (2018)

Abdullah Hazrati; Ramin Salimnejad; Mohammad Reza Alipour; Fariba Mirzaei; Alireza Alihemmati

23

Protective effect of troxerutin and cerebroprotein hydrolysate injection on cerebral ischemia through inhibition of oxidative stress and promotion of angiogenesis in rats

Molecular Medicine Reports 19(4) (2019)

Wenbing Ma; Shixiang Wang; Xuanlin Liu; Fengru Tang; Peipei Zhao; Kai Cheng; Qiaowei Zheng; Yingchen Zhuo; Xue Zhao; Xueqian Li; Weiyi Feng

25

Modulation of hippocampal gene expression of microRNA-146a/microRNA-155-nuclear factor-kappa B inflammatory signaling by troxerutin in healthy and diabetic rats

Indian Journal of Pharmacology 48(6) (2016)

Reza Badalzadeh; Raana Yavari; Mohammad Reza Alipour; Seyed Mahmoud Tabatabaei

26

The effect of swimming exercise and powdered-Salicornia herbacea L. ingestion on glucose metabolism in STZ-induced diabetic rats

Physical Activity and Nutrition 19(3) (2015)

Se Sil Lee; Hyo-Bin Seo; Ryu Sungpil; Tae-Dong Kwon

27

Benefits of micronutrient supplementation for reducing the risk of wet age-related macular disease and diabetic retinopathy

European Journal of Ophthalmology 30(4) (2020)

Maurízio Battaglia Parodi; Andrea Brunoro; Livia Tomasso; Gianluca Scuderi

28

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats.

PubMed 22(6) (2019)

Keyvan Mehri; Seyed Mahdi Banan Khojasteh; Banan Khojasteh Seyed Mahdi; Fereshteh Fereshteh; Zohreh Zavvari Oskuye; Hadi Ebrahimi; Roghaye Diba; Parvin Bayandor; Maryam Hosseindoost; Shirin Babri

29

The creation of selenium nanoparticles decorated with troxerutin and their ability to adapt to the tumour microenvironment have therapeutic implications for triple-negative breast cancer

New Journal of Chemistry 47(9) (2023)

Thiruvenkataswamy Saranya; Krishnamoorthy Kavithaa; Manickam Paulpandi; Sennimalai Ramya; Sureshbabu Harysh Winster; Geetha Mani; Sangeetha Dhayalan; Balachandar Vellingiri; Arul Narayanasamy

30

Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin

The Scientific World JOURNAL 2020 (2020)

Hamad Abdulsalam Hamad Alfarisi; Muhammad Ibrahim; Zenab B. Hamad Mohamed; Nuraniza Azahari; Asmah Hanim Hamdan; Che Anuar Che Mohamad

31

Troxerutin affects nephropathy signaling events in the kidney of type-1 diabetic male rats.

PubMed 12(2) (2022)

‬Rana Keyhanmanesh; Gholamreza Hamidian; Hajie Lotfi; Zohre Zavari; Monireh Seyfollahzadeh; Afsane Ghadiri; Mahdi Ahmadi; Farzad Bahari; Fariba Mirzaei

32

Troxerutin as an anti-inflammatory and anti-oxidative drug could ameliorate Type 1 diabetes complications in C57BL/6 mice

Journal of the Hellenic Veterinary Medical Society 74(3) (2023)

Yaser Jafari-Khataylou; Somayeh Ahmadiafshar; Navideh Mirzakhani

33

The effect of swimming exercise and powdered-Salicornia herbacea L. ingestion on glucose metabolism in STZ-induced diabetic rats

Physical Activity and Nutrition 6(1) (2015)

Se Sil Lee; Hyobin Seo; Ryu Sungpil; Tae-Dong Kwon

34

Can troxerutin pretreatment prevent testicular complications in prepubertal diabetic male rats?

Endocrine Regulations 54(2) (2020)

Afsane Ghadiri; Fariba Mirzaei; Gholamreza Hamidian; Hajar Oghbaei; Zohreh Zavvari Oskuye; Mahdi Ahmadi; ‬Rana Keyhanmanesh

35

Selected polyphenolic compounds and their use as a supportive therapy in metabolic syndrome

Česká a slovenská farmacie 71(4) (2022)

Jan Soukop; Rostislav Večeřa

36

Effect of Troxerutin on Oxidative Stress Induced by Myocardial Ischemia / Reperfusion in Diabetic Rats

Scientific Journal of Kurdistan University of Medical Sciences 26(7) (2022)

Hatam Ahmadi; Homiera Hatami Nemati; Reza Badalzadeh

37

Levels of Oxidative Stress and Inflammation in the Right Kidney After Left Ureteral Obstruction in Male Rats Treated With Troxerutin: An Experimental Study

مجله علمی دانشگاه علوم پزشکی رفسنجان 22(12) (2024)

Ayat Kaeidi; Jalal Hassanshahi

38

Potential Anti-ulcerogenic Effect of Troxerutin in Ethanol-induced Gastric Lesions in Mice: Anti-inflammatory and Antioxidant Mechanisms and Possible Action Pathways

Revista Brasileira de Farmacognosia 35(2) (2025)

Francisco Rafael Oliveira da Silva; Conceição da Silva Martins; Paulo Vitor de Souza Pimentel; João Francisco Câmara Neto; Matheus da Silva Campelo; Maria Elenir Nobre Pinho Ribeiro; Nágila Maria Pontes Silva Ricardo; Ícaro Gusmão Pinto Vieira; Carlos Eduardo da Silva Monteiro; Pedro Marcos Gomes Soares; Maria Luana Gaudêncio dos Santos Morais; Cássio Silva Sousa; Jefferson Almeida Rocha; Gilberto Santos Cerqueira; Gerly Anne de Castro Brito; João Antônio Leal de Miranda; Francisca Cléa Florenço de Sousa

39

Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions

Nephrology Dialysis Transplantation 41(6) (2025)

Valeria Kopytina; Vanessa A Marchant; Raquel Rodrigues‐Díez; Lucía Pascual‐Antón; Nora Toggweiler; Lisa Strahl; Jamie Kane; Antonio Tejera‐Muñoz; Marcelino Cortés; David Sucunza; Juan J. Vaquero; Marc G. Vervloet; Dorothea Piecha; Etto C. Eringa; Marta Ruiz‐Ortega; Manuel López‐Cabrera; Guadalupe Tirma Gónzalez-Mateo

40

Troxerutin as a bioactive flavonoid: Insights into its anticancer mechanisms and therapeutic applications

European Journal of Medicinal Chemistry 313 (2026)

Priya Manna; Srijita Chatterjee; Shayeri Chatterjee Ganguly; Sankhadip Bose; Gitishree Das; Han-Seung Shin; Jayanta Kumar Patra

41

The role of melatonin in attenuation of vascular endothelin-1 reactivity via calcium channels and endothelial derived relaxing factors in STZ-induced diabetic aortic rats

Journal of Muscle Research and Cell Motility 47(2) (2026)

Chrakhan J. Khdhir; Ridha Hassan Hussein; Ismail M. Maulood