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https://doi.org/10.5812/ijem.5034

GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

Author(s):
Pilar AlamaPilar Alama1, Jose BellverJose Bellver2, Carmen VidalCarmen Vidal1, Juan GilesJuan Giles1,*
1Department of Reproduction, IVI-Valencia, Plaza de la Policia Local, Valencia, Spain
2Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine. University of Valencia, Valencia, Spain
International Journal of Endocrinology and Metabolism:Vol. 11, issue 2; 107-16
Published online:Mar 31, 2013
Article type:Review Article
Received:Jul 08, 2012
Accepted:Aug 17, 2012
How to Cite:Alama P, Bellver J, Vidal C, Giles J. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome. Int J Endocrinol Metab. 2013;11(2):. doi: https://doi.org/10.5812/ijem.5034

Abstract

Abstract:

The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

Keywords
Ovarian Stimulation
Ovarian Hyperstimulation Syndrome
Prevention
GnRH Agonist
GnRH Antagonist

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