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Introduction:
The dexamethasone test has been widely used for diagnosing hypercortisolism.
International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease
Authors
*Corresponding Author: Department of Endocinology and Medicine, Aalborg Hospital, laurberg@aas.nja.dk, Denmark. Email: laurberg@aas.nja.dk
Published online:Jan 01, 2004
Article type:Research Article
How to Cite:P L. Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease. Int J Endocrinol Metab. 2004;2(2):. doi:
Abstract
Materials and Methods:
We assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved Cushing's disease.
Results:
A statistically highly significant correlation was found (for urine cortisol: r = 0.66, P <0.0001; for plasma cortisol: r = 0.94, P <0.003).
Conclusions:
These findings imply that the lower the pretest cortisol values, the lower are the suppressed values. In patients with suspected Cushing's syndrome and only slightly elevated cortisol excretjon or low plasma concentration, the outcome might easily be considered normal. This point is particularly pertinent when assessing the post-treatment status.
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Copyright
© 2004, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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