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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Tetralogy of Fallot Associated With Invasive Adrenocortical Tumor in an Adult Woman
Authors
Efren Martinez-Quintana1,*, Fayna Rodriguez-Gonzalez2, Maria Pino Pino Alberiche-Ruano3, Maria Soledad Soledad Martinez-Martin4
1Cardiology Service. Insular-Materno Infantil University Hospital, efrenmartinezquintana@yahoo.es, Spain
2Ophthalmology Service. Dr. Negrn University Hospital, Spain
3Endocrinology Service. Insular-Materno Infantil University Hospital, Spain
4Anatomopathology Service. Insular-Materno Infantil University Hospital, Spain
*Corresponding Author: Alcalde Ramirez Bethencourt, 10, 3-A-35003, efrenmartinezquintana@yahoo.es, Spain. Tel: +34-928373050. Fax: +34-928373050. Email: efrenmartinezquintana@yahoo.es
Published online:Apr 20, 2012
Article type:Case Report
Received:Dec 10, 2011
Accepted:Feb 04, 2012
How to Cite:Martinez-Quintana E, Rodriguez-Gonzalez F, Alberiche-Ruano MP, Martinez-Martin MS. Tetralogy of Fallot Associated With Invasive Adrenocortical Tumor in an Adult Woman. Int J Endocrinol Metab. 2012;10(2):. doi: https://doi.org/10.5812/ijem.3769
Abstract
Migration of cardiac neural crest cells into the pharyngeal arches and the pharyngeal and splanchnic mesoderm contributes to the development of the cardiac outflow tract. The adrenal cortex is derived from the splanchnic mesoderm. Neuroblastoma is more prevalent in patients with congenital heart disease than in the general population, because both originate from embryonal neural crest-derived cells. Similarly, and in light of recent embryological findings, abnormal development or migration of splanchnic mesoderm, possibly due to an underlying genetic defect, could contribute to the association of adrenocortical carcinoma and tetralogy of Fallot. We present the case of a cardiologically asymptomatic 49-year-old woman with total correction of tetralogy of Fallot in the first year of life.
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© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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