The Effect of Moderate Hypothermia on Renin- Angiotensin- Aldosterone System in Male Rats

M Kourosh Arami; S Khamenei; N Zarghami; M Vahabian

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

The Effect of Moderate Hypothermia on Renin- Angiotensin- Aldosterone System in Male Rats

Author(s):

M Kourosh Arami^1,*,

S Khamenei²,

N Zarghami²,

M Vahabian³

1Department of Physiology, Hamedan University of Medical Sciences, [email protected], Iran

2Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Iran

3Department of Physiology, Hamedan University of Medical Sciences, Iran

International Journal of Endocrinology and Metabolism:Vol. 3, issue 3; 111-115

Published online:Jul 31, 2005

Article type:Research Article

Received:Jan 15, 2005

Accepted:Aug 22, 2005

How to Cite:Kourosh Arami M, Khamenei S, Zarghami N, Vahabian M. The Effect of Moderate Hypothermia on Renin- Angiotensin- Aldosterone System in Male Rats. Int J Endocrinol Metab. 2005;3(3):. doi:

Abstract

Despite the diversity of studies on hypothermia, many of its biologic and physiologic effects are still poorly recognized. In this study the effect of hypothermia on the renin- angiotensin- aldosterone axis was explored. Materials and Methods: Ten male albino wistar rats after anesthetizing by chloral hydrate (0.5 m1/100gr body weights) were cooled to 25oC. Before and just after hypothermia, and once every 24 hours for three days; serum levels of agiotensin I and aldosterone were measured, using the radioimmunoassay method. Plasma renin activity was also determineded by the standard formula for angiotensin determinates at two temperatures of 4oC and 37oC. Results: Plasma renin activity increased during hypothermia but then decreased to a level not significantly different from basal values. Angiotensin I increased significantly in the second sample taken 24 hours following hypothermia (p<0.05) and then decreased to the basal range by 72 hours. Serum aldosterone level rose significantly until 48 hours following hypothermia, after which it began to decrease and returned to basal level. Conclusion: Results of this study advocate the stimulating effect of moderate hypothermia on plasma renin activity, angiotensin I and aldosterone.

Keywords

Hypothermia

Renin- angiotensinaldosterone

Rat

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 2
Last Update: 1 week ago
CrossRef: 0
Last Update: 5 hours ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

M Kourosh Arami:[PubMed][Scholar]
S Khamenei:[PubMed][Scholar]
N Zarghami:[PubMed][Scholar]
M Vahabian:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

The Effect of Moderate Hypothermia on Renin- Angiotensin- Aldosterone System in Male Rats

Abstract

Full Text

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 5 hours ago