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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Ethnicity, Smoking and Body Composition Influence Testosterone and Estradiol Levels in Healthy Young Adult Men in Malaysia: A Pilot Study
Authors
1Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur Malaysia
2Biochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
*Corresponding Author: Department of Pharmacology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Tel: +60-340405514, Fax: +60-326938205 Email: imasoel@medic.ukm.my
Published online:Jan 31, 2012
Article type:Research Article
Received:Nov 28, 2011
Accepted:Jan 01, 2012
How to Cite:Chin KY, Soelaiman IN, Mohamed IN, Johari H, Wan Ngah WZ. Ethnicity, Smoking and Body Composition Influence Testosterone and Estradiol Levels in Healthy Young Adult Men in Malaysia: A Pilot Study. Int J Endocrinol Metab. 2012;10(1):. doi: https://doi.org/10.5812/ijem.3937
Abstract
Background: Variations in sex hormone levels can be caused by differences in ethnicity, smoking habits, and body composition and may be related to racial differences in the prevalence of certain diseases.
Objectives: This study examined the effects of ethnicity, smoking, and body composition on testosterone and estradiol levels in a group of young Malaysian men.
Materials and Methods: In this cross-sectional study, 189 Malay and Chinese men aged 20-39 years answered a detailed questionnaire, underwent body anthropometric measurements, and had their blood drawn for hormone assays.
Results: The results indicated no differences in testosterone levels between races (P>0.05), but estradiol levels were significantly higher among Malay compared with Chinese men (P<0.05). No difference was detected in sex hormone levels between smokers and non-smokers (P>0.05). However, smokers with more than 10 years of cigarette smoke exposure had a significantly higher estradiol level than smokers with 1-5 years of exposure (P<0.05). Testosterone (total, free, and non-SHBG-bound) levels correlated inversely and significantly (P<0.05) with body mass index (BMI), waist-to-hip circumference ratio (WHR), and percentage of body fat. By multiple stepwise regression, body fat percentage was the most influential predictor of testosterone (β=-0.456 for total, β=-0.279 for free, β= -0.297 for non-SHBG-bound fraction) and SHBG levels (β=-0.172).
Conclusions: Estradiol levels are influenced by ethnicity and duration of smoking, whereas testosterone levels are governed by body fat percentage in Malaysian young adult males.
The factors that influence sex hormone levels suggested in this study may explain the differences in the prevalence of disease in populations with distinct demographics and behavior. It also suggests possible areas for behavior modification in order to prevent sex hormone dependent diseases from developing.
Chin KY, Soelaiman IN, Mohamed IN, Joharj H, Wan Ngah WZ. Ethnicity, Smoking and Body Composition Influence Testosterone and Estradiol Levels in Healthy Young Adult Men in Malaysia: A Pilot Study. Int J Endocrinol Metab. 2012; 10(1): 404-10. DOI: 10.5812/ijem.3937
Copyright © 2012 Kowsar M. P. Co. All rights reserved.
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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