Innovative Journal of Pediatrics
The Scientific Journal of Growth & Development Research Center
e-ISSN 3117-5341
Image Credit:Inn J Pediatr
Outline
Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation
Authors
Dusica Stojanović1, Marina Jonovic2, Stevo Najman3, Bojko Bjelakovic4, Zoran Pop-Trajkovic2, Gordana Kocic5, Ljiljana Bjelakovic4,*
1Department of Hygiene, Faculty of Medicine, University of Nis, Serbia
2Clinical Center, Clinic of Obstetrics and Gynecology, Nis, Serbia
3Institute of Genetics, Faculty of Medicine, University of Nis, Serbia
4Department of Hygiene, Faculty of Sport and Physical Education, University of Nis, Serbia
5Department of Biochemistry, Faculty of Medicine, University of Nis, Serbia
*Corresponding Author: Department of Hygiene, Faculty of Sport and Physical Education, University of Nis, Serbia Email: ljilja975@gmail.com
Published online:Jun 30, 2012
Article type:Research Article
Received:Dec 22, 2008
Accepted:Jul 06, 2009
How to Cite:Stojanović D, Jonovic M, Najman S, Bjelakovic B, Pop-Trajkovic Z, et al. Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation. Inn J Pediatr. 2015;22(2):. doi:
Abstract
Objective: Human milk (HM) is the ideal food for all newborns and infants. Apart from various bioactive compounds, including cytokines, antibodies, hormones, vitamines, it also contains polyamines, such as spermine (Sp), spermidine (Spd) and putrescine (Put).
Aim: The present study investigated polyamine metabolism in colostrum and mature human milk by measuring the polyamine oxidase (PAO) and diamine oxidase (DAO) enzyme activities, which are necessary for polyamine catabolism, as well as by determining the malondialdehyde (MDA) levels, the final product of polyamine biodegradation.
Methods: The PAO, DAO activity and MDA levels were quantified in colostrum (1st and 2nd day) as well as in mature human milk, 30th day of lactation.
Findings: We found the steady increase of PAO activity and steady decrease of DAO activity and MDA levels during first month of lactation.
Conclusion: Since the products of PAO activity such as, amino aldehydes and hydrogen peroxide (H2O2) might have potential antimicrobial effects, promoting the oxidative stress, it is likely that human milk PAO throughout the lactation period, contributes to the protective effects of human milk.
Highlights
References
- 1.References are available in PDF.
Copyright
© 2015, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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