Innovative Journal of Pediatrics
The Scientific Journal of Growth & Development Research Center
e-ISSN 3117-5341
Image Credit:Inn J Pediatr
Outline
Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis
Authors
Published online:Oct 07, 2013
Article type:Review Article
Received:Jan 10, 2013
Accepted:Sep 13, 2013
How to Cite:Zou Y, Li H, Ding G. Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis. Inn J Pediatr. 2013;23(6):. doi:
Abstract
Objective: To systematically evaluate therapeutic success of the ketogenic diet (KD) as a treatment option for epilepsy. Methods: Using MEDLINE and Google Scholar search, we searched for studies investigating the therapeutic success of ketogenic diet for epilepsy. We estimated therapeutic success rate for ketogenic diet as a treatment option for epilepsy and its 95% CIs using generic inverse variance method. Findings: A total of 38 studies met the inclusion criteria. In retrospective studies, the weighted success rate of the patients who take the KD as a treatment option for epilepsy was 58.4% (95% confidence interval (95%CI)=48.7% - 69.9%) at 3 months (n=336); 42.8% (95%CI =36.3% - 50.3%) at 6 months (n=492), and 30.1% (95%CI =24.3% - 37.2%) at 12 months (n=387); in prospective studies, weighted success rate was 53.9% (95%CI 45.5% - 63.8%) at 3 months (n=474); 53.2% (95%CI =44.0% - 64.2%) at 6 months (n=321), and 55.0% (95%CI =45.9% - 65.9%) at 12 months (n=347). Conclusion: This meta-analysis provides formal statistical support for the efficacy of the ketogenic diet in the treatment of epileptic patients.
Highlights
References
- 1.References are available on the PDF.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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