Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Free prolactin receptor status in breast cancer
Authors
Abstract
Abstract Background: Prolactin simulates the development and differentiation of breast cells. This hormon is mediated by its binding to the specific membrane receptor. Objective: To evaluate the free prolactin receptor (PRO-R) status in malignant tumors of the breast. Methods: Free PRO-R was estimated in the membrane of 40 breast cancer tumors by ligand binding assay. Findings: The results indicated that 45% of tumors have specific binding greater than 1% of radioactivity which was defined to be positive for PRO-R. Grade II and III tumors had 54% and 40% PRO-R respectively. 40% of the patients with lymph node involvment and 64% without lymph node involvement were observed to be positive for PRO-R. 40% of premenopauses and 50% of postmenopauses had PRO-R +. Conclusion: Some breast cancer tumors have lymph node involvement.
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
Evaluation of binding of FITC-prolactin conjugate to prolactin receptor
sirati Sabet M, Karami Tehrani F. Evaluation of binding of FITC-prolactin conjugate to prolactin receptor. J Inflamm Dis. 2024;10(4):e155258. doi:
Comparison of Hormone Receptor Status in Primary and Recurrent Breast Cancer
Saeedi Saedi H, Ghavam Nasir M, ShahidSales S, Taghizadeh A, Mohammadian N. Comparison of Hormone Receptor Status in Primary and Recurrent Breast Cancer. Int J Cancer Manag. 2012;5(2):e80803. doi:
The Differences of Age, Tumor Grade, and Her2 Amplification in Estrogen and Progesterone Receptor Status in Patients with Breast Cancer
Sheikhpour E, Taghipour S. The Differences of Age, Tumor Grade, and Her2 Amplification in Estrogen and Progesterone Receptor Status in Patients with Breast Cancer. Int J Cancer Manag. 2018;11(8):e9492. doi: https://doi.org/10.5812/ijcm.9492
Effects of estradiol, progesterone and testosterone on proliferation of human breast cancer cell lines
hashemi M, Ghavami S. Effects of estradiol, progesterone and testosterone on proliferation of human breast cancer cell lines. Zahedan J Res Med Sci. 2005;7(1):e94974. doi:
Comparison of ER, PR, Ki67 and HER-2/neu Reactivity Pattern with Patients’ Age, Histologic Grade, Tumor Size and Lymph Node Status in Invasive Ductal Breast Cancer
Ahadi M, Heibatollahi M, Zahedifard S. Comparison of ER, PR, Ki67 and HER-2/neu Reactivity Pattern with Patients’ Age, Histologic Grade, Tumor Size and Lymph Node Status in Invasive Ductal Breast Cancer. Int J Cancer Manag. 2020;13(6):e98325. doi: https://doi.org/10.5812/ijcm.98325
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 1 day ago