Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Role of Capsanthin on analgesia and jumping induced Naloxone in Morphine dependent mice
Authors
Abstract
Background: Red pepper is frequently used as a therapeutic agent in traditional medicine. Objective: To study the analgesic effect of capsanthin and its effect on morphine dependent mice. Methods: Analgesia was measured by tail-flick test. The degree of dependence on morphine was determined by the number of jumpings, five minutes after the induction of naloxone. Findings: Capsanthin (25, 50, 75 mg/kg) with morphine (10 mg/kg) had significant analgesic effect compared with morphine alone. Morphine dependent mice which received capsanthin differed in jumping rate compared with the control group. Jumping latency time increased significantly in capsanthin groups (Particularly in 50, 75 mg/kg). Conclusion: Capsanthin together with morphine has significant analgesia effects in comparison with morphine alone.
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© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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