Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Evaluation of analgesic and ulcerogenic effect of Methanolic extract of Matricaria Chamomilla L
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Abstract
Background: Matricaria chamomilla L has a particular position as analgesic, anxiolitic and carminative in traditional medicine. Objective: To evaluate the analgesic and ulcerogenic effect of methanolic extract of matricaria chamomilla L. Methods: This plant was extracted by suxhlet and percolation methods by methanol 80%. The extract was then concentrated and the weight of direct extract was determined and dissolved in normal salin to produce a different desired concentration. The analgesic effect was evaluated by formalin and hot-plate test in mice and the ulcerogenic effect was studied in rats. Findings: The results indicated that the analgesic effect of percolation extract is higher than the suxhlet extract (P<0.01). The percolation extract with dose of 200 mg/kg which was injected intra-peritoneally to mice and its analgesic effect evaluated by hot-plate test revealed a significant effect to normal salin (P<0.05). The extract did not induce gusteric ulcer. Conclusion: The results showed that the analgesic effect of the extract was not mediated via opiate system and probably meditated via its anti-inflammatory effect.
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© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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