Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Comparison of urinary Neopterin to Creatinin ratio in Multiple Sclerosis patients and controlled group
Authors
Abstract
Abstract Background: Multiple Sclerosis as the most common cause of demyelinating disorders and has a basis of autoimmunity. Objective: To describe a procedure to determine total and aromatic UNCR and their ratio as a marker of cell mediated immunity in MS patients and controlled groups. Methods: In this project UNCR was determined and compared in MS patients who referred to the neurology department of Shariati's Hospital and normal subjects using HPLC and Novapak C18 (3.9x300mm) column at 25 degrees centigrade. Findings: Mean of aromatic UNCR were 337.6±47.2 and 1273.1±201.64 micromol/mol, mean of total UNCR were 484.64±60.2 and 1800.3±250.1 micromol/mol, and the ratio of aromatic/total UNCR were 0.664 and 0.73 in normal subjects and MS patients respectively. Conclusion: Prominent elevation of aromatic UNCR in MS patients in comparison with normal subjects is the sign of high activity of cell-mediated immunity in this group even though with treatment.
Highlights
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
Assessment of serum magnesium, copper, and zinc levels in multiple sclerosis (MS) patients
Masoud SA, Fakharian E. Assessment of serum magnesium, copper, and zinc levels in multiple sclerosis (MS) patients. Iran J Psychiatry Behav Sci. 2007;1(2):. doi:
Comparing the Cognitive Function in Multiple Sclerosis Patients
Raghibi M, khosravy M. Comparing the Cognitive Function in Multiple Sclerosis Patients. Zahedan J Res Med Sci. 2012;14(2):e93580. doi:
Prevalence of bladder and sexual dysfunctions in patients with multipl
Mazdeh M, Jafari M. Prevalence of bladder and sexual dysfunctions in patients with multipl. J Inflamm Dis. 2024;12(4):e155433. doi:
Serum IgG Level and IgG/IgM Ratio on Admission Predict Steroid-Resistant Response in Vietnamese Children with Idiopathic Nephrotic Syndrome
Le Viet T, Nguyen Trung K, Do Manh H, Truong Quy K, Pham Van T, et al. Serum IgG Level and IgG/IgM Ratio on Admission Predict Steroid-Resistant Response in Vietnamese Children with Idiopathic Nephrotic Syndrome. Nephro-Urol Mon. 2019;11(3):e93248. doi: https://doi.org/10.5812/numonthly.93248
Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran
Najafi S, Ghane M, Poortahmasebi V, Jazayeri SM, Yousefzadeh-Chabok S. Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran. Jundishapur J Microbiol. 2016;9(7):e36582. doi: https://doi.org/10.5812/jjm.36582
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 5 days ago
- OpenAlex: 0
Last Update: 2 hours ago
- OpenCitations: 0
Last Update: 2 days ago