Radiological study of Down’s syndrome in Tehran and Shiraz

Background: Down’s syndrome as the most common chromosome disorder is associated with some radiological changes. Objective: This study was performed to determine the radiological changes in Down’s syndrome in Iran. Methods: This cross-sectional study was done on 51 clients in exceptional and welfare centers of Tehran and Shiraz in the year 2001. Using X-ray films from hands and pelvis of 51 Down’s syndrome patients, the carpal, iliac, and acetabular angles were measured. Also the bone age was estimated and patients with osteoporosis were determined. These findings were compared with normal values. Findings: Acetabular and iliac angles in DS subjects were smaller than normal. In 76.5% of cases, the carpal angle were larger than average of healthy people. There was a significant correlation between calender age and ratio of bone age to calender age (r=+0.431 t=2.28 df=34 P<0.005). The most interesting finding it was the relationship between IQ level and frequency of osteoporosis in samples. Conclusion: The pre data showed that the radiological findings of Down’s syndrome subjects in Iran were the same as in the other populations.