Comparison of vaginal suppository and intravenous PGE2 in termination of pregnancy at midtrimester

F Movahed; G Mohammad Abrahim

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

Authors Guide Submit Manuscript

Comparison of vaginal suppository and intravenous PGE2 in termination of pregnancy at midtrimester

Author(s):

F Movahed,

G Mohammad Abrahim^,*

Journal of Inflammatory Diseases:Vol. 7, issue 4; 58-62

Published online:Dec 31, 2003

Article type:Research Article

How to Cite:Movahed F, Mohammad Abrahim G. Comparison of vaginal suppository and intravenous PGE2 in termination of pregnancy at midtrimester. J Inflamm Dis. 2024;7(4):e154985. doi:

Abstract

Background:There are several methods for abortion either surgical or medical and one of them is the usage of prostaglandins. Objective: Comparison of efficacy of vaginal suppository and IV PGE2 in induction of labor at midtrimester. Methods: This single blind clinical trial was done on 36 pregnant women attending on Kosar hospital in Qazvin during 2002. Indications for termination of pregnancy were reduction of amniotic fluid or intrauterin fetal death. Patients were divided randomly into two equal groups. In first group two suppositories of vaginal PGE2 (3mg) was administered (interval 4 hours). In second group 5 mg of IV PGE2 was applied (diluted in 1000cc 5% dextrose serum) and according to necessity , the dosage of this drug was increased . If abortion did not happen, oxytocin was administered 12 hours later untill abortion occurred. Then results in two groups were compared with T test, and Chi-squre. Findings: Patients of two groups were identical (gestational age, parity , indication of termination). Frequency of abortion before induction in IV PGE2 group was significantly more than vaginal PGE2 groups (14 patients (77.8%) , 2 patients (11.1%) respectively , P<0.0001) .About the changes in Bishop score, amount of applied oxytocin, and the need to curretage after abortin there were no significant differnce between two groups. But duration from induction to expulsion of fetus in IV PGE2 group was significantly less than vaginal PGE2 group (7.3 0.96 hours against 11.1 5.6 hours and P=0.019 ). In 2 patients (11.1%) of vaginal PGE2 group and 8 patients (44.4%) of IV PGE2 group drug complication were detected (P = 0.026). Conclusion: Efficacy of IV PGE2 in induction of abortion in midtrimester is better than vaginal PGE2 and it has not serious maternal complications.

Keywords

Intravenous PGE2

Vaginal Suppostitory of PGE2

Induction of Abortion

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 0
Last Update: 1 week ago
CrossRef: 0
Last Update: 6 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

F Movahed:[PubMed][Scholar]
G Mohammad Abrahim:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

Comparison of vaginal suppository and intravenous PGE2 in termination of pregnancy at midtrimester

Abstract

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 6 days ago