The obsessive - compulsive disorder: prevalence and therapy in psychiatric clinic clients at Nour hospital of Isfahan (1995-1997)

¯Abstract Background: The obsessive-compulsive disorder (OCD), is a common psychiatric disease and in spite of long-term treatment, its failure to therapy, discontinuing, relapse and side effects are high. Objective: This study was done to assess the patterns of OCD, prevalence, therapies and comorbidity in Nour psychiatric clinic clients. Methods: Within 3515 psychiatric consultation during 4 years, 166 cases of OCD were recognized. The time of initial and complete drug effects considered 3 and 6 weeks respectively. The response to therapy (after 6 weeks) was:1 (Good: symptoms remove, 2) Medium: symptoms relief, 3) Poor: no symptoms control. Findings: The prevalence of OCD were 4.72%, mainly women, married and adult with 20-40 years old. The most pattern of OCD was washing, thinking and checking, respectively. The most used drug was clomipramine (66.87%) then fluoxetine (19.27%), with dosage 61-100 and 20 (mg/d) respectively. In group 1, the mean dose of clomipramine and fluoxetine was 69 and 60 (mg/d). Only 30.1% of cases had been followed up, and 13.2% of them had good response to therapy. The comorbidity was in 68.08% of cases, and in 80.64% of them, the response to therapy was mild. The most psychiatric comorbidity was major depression disease (44.57%). Conclusion: The prevalence of OCD is high. The most used drug (insufficient and not enough), was clomipramine then fluoxetine. The psychiatric comorbidity (specially major depression disease) had raised failure rate.