The comparison of different antibiotics in treatment of acute otitis media in children

Abstract Background: Acute otitis media is the most prevalent disease of childhood following respiratory tract infections. In addition, several complications which may be life treatening can occure. Objective: This study was performed to determine the clinical responses of acute otitis media to different antibiotics and also the selection of most suitable antibiotic for treatment. Methods: In this study, 141 individuals with acute otitis media were visited as out patients in Amir-Al-Momenine Hospital and private clinics by ENT Specialists. The patients for whom no antibiotic was preseribed for the last episode of disease, were randomly divided into four groups and each group was given a ten-day course of Treatment with one of following antibiotics: Amoxcillin, co-amouxy clav, cefixim and co-trimaxazole. Twelve to sixteen days following the treatment the clinical responses were evaluted using Chi-Square test to investigate the hypothesis. Findings: Clinical in group with coAmoxyclav 86.6%, Amoxycillin 84.4%, cefixim 83.9% and cotrimxazol 80.6% improvement was observed. Statistically, no significant difference was fount between four groups. Conclusion: The data of this study showed that the efficacy of these antibiotics to treat the uncomplicated acute otitis media is equal.