Evaluation of correlation between fructosamine and glycated hemogolobin

Abstract Background: Fructosamine or glycated plasma proteins are used to assess the short term diabetes control. Fructosamine concentration dependends on blood glucose level, protein concentration and halflife of proteins. Some have reported that measuring fructosamine without considering protein concentration is of no value. Objective: To investigate the ralation between fructosamine, albumin and total proteins and also the effect of fructosamine correction on capacity of this assay to assess the glycemic condition. Methods: Fifty diabetic patients from diabetes center in Yazd (Iran) were selected. The levels of fructosmine, albumin and total protein were determined once a month for a duration of two months followed by measurement of glycatd hemoglobim after two months. Fructosamine and glycated hemoglobin were measured by colorometric method based on nitro blue tetrazulium and ion exchange chromatography method, respectively. Findings: The correlation between glycatde hemoglobin and fructosamine, fructosamine corrected with albumin and total protein were 0.941, 0.908 and 0.9 (P<0/001). No correlation was found between fructosamine, albumin, and total protein. Mean of albumin and total proteins were 4.3 and 6.3 g/dl. Conclusion: Regarding our data, fructosamine correction at normal range of albumin and total protein did not affect fructosamine capacity in assessing diabetes control and under such condition albumin and total protein showed no effect on fructosamine