Evaluation of correlation between pre- eclampsia with D-Dimer

Abstract Background: Recently, D- dimer has been designated as a biomarker with potential for diagnosis & management of pre-eclampsia. Objective: To determine the correlation between pre-eclampsia and D-dimer and also comparing of results with those of control group obtained at third trimester. Methods: This was a descriptive analytical study performed on pregnant women at their third trimester. The patients were divided into two groups of 30 members marked as case group with pre-eclampsia and control group with normal pregnancy. Plasma level of D-dimer was quantitatively measured by agglutination technique. Findings: Pre-eclampsia showed a significant correlation with plasma D-dimer. In third trimester, pre-eclamptic women were demonstrated to have significantly higher levels of D-dimer compared with normal pregnant women, 721.43401.13 vs. 322.26117.65 ng/ml (P<0.001). D-dimer was also shown to have a positive correlation with severity of condition in pre-eclamptic women. Conclusion: Regarding the data obtained in present study, plasma D-dimer level may be a potential biomarker for hematologic and fibrinolytic changes occurs in pre-eclampsia. Also, D-dimer could be considered as a biomarker to evaluate the risk factors of pre-eclampsia.