Effects of morphine-treated fetal mice on spatial learning after birth

M H Esmaeili; M Sofiabady; F Rajaei; H Jahany Hashemy

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Effects of morphine-treated fetal mice on spatial learning after birth

Author(s):

M H Esmaeili^,*,

M Sofiabady,

F Rajaei,

H Jahany Hashemy

Journal of Inflammatory Diseases:Vol. 11, issue 4; 31-35

Published online:Mar 31, 2008

Article type:Research Article

How to Cite:Esmaeili M H, Sofiabady M, Rajaei F, Jahany Hashemy H. Effects of morphine-treated fetal mice on spatial learning after birth.J Inflamm Dis.2008;11(4):e155357.

Abstract

Abstract Background: Drug abuse during pregnancy is a growing problem in all developed countries worldwide. Maternal drug abuse affects the developing systems and the associated long-term effects can persist untill adulthood, decreasing the rate of their maturation. Objective: To determine the effects of prenatal morphine exposure on spatial learning Methods: Eighteen pregnant rats were divided into morphine, saline, and control groups. Morphine or saline was administrated (S.C) to female rats twice a day (at 12-hr intervals) during the days 11-18 of their gestational period (5 mg/kg morphine for the first 3 days and 10 mg/kg for further 5 days). Pups (P90, n=6) were trained in an 8-arm radial maze apparatus.The data were analyzed statistically using Chi-square test. Findings: The results indicated that prenatal morphine exposure causes a reduction in the time needed to learn these trials however, they needed more time to complete regular trials. Conclusion: Prenatal morphine exposure impairs normal spatial learning.

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Author(s):

M H Esmaeili:[PubMed][Scholar]
M Sofiabady:[PubMed][Scholar]
F Rajaei:[PubMed][Scholar]
H Jahany Hashemy:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

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Effects of morphine-treated fetal mice on spatial learning after birth

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