Apoptosis: programmed cell death

Maryam Honardoost; Horyeh Soleimanjahi; Farzad Rajaei

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

Authors Guide Submit Manuscript

Apoptosis: programmed cell death

Author(s):

Maryam Honardoost,

Horyeh Soleimanjahi¹,

Farzad Rajaei

1Tarbiat Modarres University

Journal of Inflammatory Diseases:Vol. 17, issue 3; 48-57

Published online:Nov 01, 2013

Article type:Review Article

How to Cite:Honardoost M, Soleimanjahi H, Rajaei F. Apoptosis: programmed cell death. J Inflamm Dis. 2024;17(3):e155769. doi:

Abstract

Apoptosis or programmed cell death is known as a conserved gene-directed mechanism for the specific elimination of unnecessary or unwanted cells from an organism and is involved in many immune system mechanisms and diseases . The main differences of this pathway with cell necrosis as two main pathways for elimination of unwanted cells are the absence of inflammation and the restricted effect on target cells. Apoptosis has an important role in biological processes such as normal development, tissue homeostasis, elimination of destroyed cells or virus infected cells and remove of self antigen-activated immune cells. A poptosis is important for regulation of cell growth and proliferation, development and body health and many autoimmune diseases, cancers and viral infections are the result of impaired or inhibited programmed cell death . Therefore the main objective of apoptosis research is to identify molecular components and regulatory mechanisms specially Bcl-2 and IAP family as the most important regulators of apoptosis and this information may lead to application of therapeutic agents that can modulate this process in the treatment of neurodegenerative disorders and proliferative diseases such as cancer.

Keywords

Apoptosis

Programmed Cell Death

Caspase

Bcl-2 Family

IAP Family

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 389
Last Update: 1 month ago
Scopus by Title (Ref): 18
Last Update: 1 month ago
CrossRef: 0
Last Update: 6 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Maryam Honardoost:[PubMed][Scholar]
Horyeh Soleimanjahi:[PubMed][Scholar]
Farzad Rajaei:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

Apoptosis: programmed cell death

Abstract

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 6 days ago