Immunohistochemical study of ki-67 and bcl-2 expression in some odontogenic cystic lesions with different clinical behaviors

seysd hosein tabatabaei; Shokouh  Taghipour zahir; Samane Keshavarz; F Khajehzade

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

Authors Guide Submit Manuscript

Immunohistochemical study of ki-67 and bcl-2 expression in some odontogenic cystic lesions with different clinical behaviors

Author(s):

seysd hosein tabatabaei,

Shokouh Taghipour zahir,

Samane Keshavarz^,*,

F Khajehzade

Journal of Inflammatory Diseases:Vol. 20, issue 4; 12-4

Published online:Nov 30, 2016

Article type:Research Article

How to Cite:tabatabaei SH, Taghipour zahir S, Keshavarz S, Khajehzade F. Immunohistochemical study of ki-67 and bcl-2 expression in some odontogenic cystic lesions with different clinical behaviors. J Inflamm Dis. 2024;20(4):e155976. doi:

Abstract

Background: Cystic lesions with odontogenic epithelial origin and similar clinicoradiographic appearance, show different clinical behaviors. Objective: To compare some factors related to cell proliferation and escape from apoptosis in epithelium covering two groups of odontogenic cystic lesions with different clinical behaviors. Methods: In this cross-sectional study 11 paraffin-embedded samples were selected of each lesions radicular cyst, dentigerous cyst, odontogenic keratocyst, and unicystic ameloblastoma. The sample underwent immunohistochemical staining for investigating the expression of ki-67 antigen and bcl-2 protein. Data analyzed with SPSS17 software and Kruskal–Wallis and chi-square statistical tests. Findings: Most of ki-67 positive cells were observed in parabasal layer of odontogenic keratocyst [35.50±26.29%; P=0.001]. The average of ki-67-LI was more in parabasal layer of aggressive group (26.80±37.79%) compared to non-aggressive group (4.04±3.38%), was not being statistically significant. The highest average of bcl-2-LI was 95±6.70% in basal layer of odontogenic keratocyst (P=0.001). In all layers, the average of bcl-2-LI was more in aggressive lesions compared to non-aggressive ones and the highest amount was found in basal layer (72.45±3.94×10%) which was statistically significant (P=0.001). Conclusion: According to the results of this study, more expression of the markers related to escape from apoptosis in aggressive lesions group compared to non-aggressive group, suggests that escape from apoptosis had a more critical role in aggressive behavior of odontogenic cystic lesions.

Keywords

bcl-2 Protein

ki-67 Antigen

Immunohistochemical Staining

Odontogenic Cystic Lesions

Prevalence of Odontogenic Tumors and Cysts in Iran: A Systematic Review and Meta-analysis

Fahimeh Feili,

Mohamadali Roozegar

Feili F, Roozegar M. Prevalence of Odontogenic Tumors and Cysts in Iran: A Systematic Review and Meta-analysis. Int J Cancer Manag. 2025;18(1):e157286. doi: https://doi.org/10.5812/ijcm-157286

7

Feb

2018

Prognostic Value of P63, Maspin, and MMP-2 Expression in Salivary Gland Adenoid Cystic Carcinoma

Nasim Taghavi,

Parisa Kardouni Khozestani,

Farzad Yazdani,

Alireza Akbarzadeh Baghban

Taghavi N, Kardouni Khozestani P, Yazdani F, Akbarzadeh Baghban A. Prognostic Value of P63, Maspin, and MMP-2 Expression in Salivary Gland Adenoid Cystic Carcinoma. Int J Cancer Manag. 2018;11(2):e7564. doi: https://doi.org/10.5812/ijcm.7564

6

Feb

2022

Immunohistochemical Evaluation of Transforming Growth Factor-β Expression in Oral Lichen Planus

Narges Ghazi,

Nasrollah Saghravanian,

Ala Ghazi,

Mohammad Ghadirifard

Ghazi N, Saghravanian N, Ghazi A, Ghadirifard M. Immunohistochemical Evaluation of Transforming Growth Factor-β Expression in Oral Lichen Planus. Int J Cancer Manag. 2021;14(12):e116421. doi: https://doi.org/10.5812/ijcm-116421

2

Jul

2022

Evaluation of Matrix Metalloproteinases 2 and 9 in Oral Squamous Cell Carcinoma and Verrucous Carcinoma

Maryam Shahsavari,

Siavash Azizi Mazreah,

Azadeh Shoghi,

Razieh Gheysari

Shahsavari M, Azizi Mazreah S, Shoghi A, Gheysari R. Evaluation of Matrix Metalloproteinases 2 and 9 in Oral Squamous Cell Carcinoma and Verrucous Carcinoma. Int J High Risk Behav Addict. 2022;11(2):e109491. doi: https://doi.org/10.5812/ijhrba-109491

30

Jun

2013

Frequency of odontogenic cysts and tumors associated with the impacted teeth in Babol dental faculty (2003-2010)

M Seyedmajidi,

Sh Nafarzadeh

Seyedmajidi M, Nafarzadeh S. Frequency of odontogenic cysts and tumors associated with the impacted teeth in Babol dental faculty (2003-2010). J Inflamm Dis. 2024;17(1):e155750. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 0
Last Update: 1 month ago
Scopus by Title (Ref): 0
Last Update: 1 month ago
CrossRef: 0
Last Update: 4 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

seysd hosein tabatabaei:[PubMed][Scholar]
Shokouh Taghipour zahir:[PubMed][Scholar]
Samane Keshavarz:[PubMed][Scholar]
F Khajehzade:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

Immunohistochemical study of ki-67 and bcl-2 expression in some odontogenic cystic lesions with different clinical behaviors

Abstract

Similar Articles

Prevalence of Odontogenic Tumors and Cysts in Iran: A Systematic Review and Meta-analysis

Prognostic Value of P63, Maspin, and MMP-2 Expression in Salivary Gland Adenoid Cystic Carcinoma

Immunohistochemical Evaluation of Transforming Growth Factor-β Expression in Oral Lichen Planus

Evaluation of Matrix Metalloproteinases 2 and 9 in Oral Squamous Cell Carcinoma and Verrucous Carcinoma

Frequency of odontogenic cysts and tumors associated with the impacted teeth in Babol dental faculty (2003-2010)

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 4 days ago