Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Determining minimum inhibitory concentration growth rate and sensitivity of Yersinia to beta-lactam antibiotics
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Abstract
Background: Diarrhea is one of the most important causes of children mortality in developing countries. Gastroenteritis causes mortality in children younger than five years old annually. The presence of antibiotics resistance species among these bacteria are major health problems. Objective: This study aimed to determine the antibiotic susceptibility and MIC50%, MIC90% of Yersinia to three beta-lactam antibiotics. Methods: This experimental study was determined sensitivity of different species of Yersinia to three beta-lactam antibiotics (Ampicillin-Cefazolin-Cefotaxime). In total 50 species (39 from different human sources, environments, foods and 11 from Pasteur institutions in Paris) were used. Minimum inhibitory concentration (MIC) was carried out by serial dilution method. Findings: Among three tested antibiotics, the lowest MIC 50%, MIC 90% were obtained for Cefotaxime (≥0.125μg/ml and 0.5μg/ml). All the tested species showed resistance to Ampicillin and very low sensitivity toward Cefazolin. Conclusion: The results showed that Cefotaxime was more effective against Yersinia species in compared to Ampicillin and Cefazolin.
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© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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