Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

Reza Najafipour; Zahar Rashvand; Khadijeh Taherkhani; Solmaz Chamanara; Shokoh Abotorabi; Sahar Moghbelinejad

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

Author(s):

Reza Najafipour¹,

Zahar Rashvand¹,

Khadijeh Taherkhani¹,

Solmaz Chamanara²,

Shokoh Abotorabi²,

Sahar Moghbelinejad^1,*

1Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

2Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 3; 169-174

Published online:Dec 31, 2021

Article type:Research Article

How to Cite:Najafipour R, Rashvand Z, Taherkhani K, Chamanara S, Abotorabi S, et al. Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women. J Inflamm Dis. 2024;25(3):e156290. doi:

Abstract

Background: It has been reported that less than 5% of women experience recurrent pregnancy loss (RPL). different matrix metalloproteinases (MMPs) have proteolysis function with a main role in the stable development of the fetus. Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls. Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method. Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P<0.01) and A allele (OR:1.95, 95% CI:0.95-3.1, P<0.001) of rs11225395 G>A polymorphism in patients compared to controls. This high frequency was also reported in the haplotypes and combined genotypes of polymorphism. Conclusion: The MMP-8 gene may be involved in RPL risk and is a potential biomarker for RPL susceptibility.

Keywords

Recurrent pregnancy loss

Matrix metalloproteinase

MMP-8

Polymorphism

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Author(s):

Reza Najafipour:[PubMed][Scholar]
Zahar Rashvand:[PubMed][Scholar]
Khadijeh Taherkhani:[PubMed][Scholar]
Solmaz Chamanara:[PubMed][Scholar]
Shokoh Abotorabi:[PubMed][Scholar]
Sahar Moghbelinejad:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

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Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

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