Dyschloremia During Severe COVID‑19 Infection in Intensive Care Unit Patients

marayam gheraati; Monirsadat Mirzadeh; fateme nazifi; Negar Davoodi; Atefeh Khoshkchali

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Dyschloremia During Severe COVID‑19 Infection in Intensive Care Unit Patients

Author(s):

marayam gheraati¹,

Monirsadat Mirzadeh

¹,

fateme nazifi²,

Negar Davoodi^1,*,

Atefeh Khoshkchali¹

1Metabolic Diseases Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

2Department of Critical Care Nursing, Faculty of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 26, issue 4; 201-208

Published online:Mar 31, 2023

Article type:Research Article

How to Cite:gheraati M, Mirzadeh M, nazifi F, Davoodi N, Khoshkchali A. Dyschloremia During Severe COVID‑19 Infection in Intensive Care Unit Patients. J Inflamm Dis. 2024;26(4):e156327. doi:

Abstract

Background: Dyschloremia is one of the most prevalent abnormalities that is highly associated with a high level of mortality in intensive care unit (ICU) patients. The current study evaluated serum chloride levels in COVID-19 patients hospitalized in the ICU. Methods: This cross-sectional study was conducted on 245 patients with severe COVID-19 who were admitted to the intensive care unit (ICU). Electrolytes, albumin, liver function test, complete blood count, serum chloride, and VBG were among the laboratory markers compared. The Chi-square, t-test, and logistic regression models were used to examine the relationship between these markers and the key outcomes, which included severity, mortality, intubation, and hospitalization. Findings: The Mean±SD age of patients was 58.16±17 years. The mean serum chloride level in the studied patients was 109.6±5.1 with a range of 100-134. According to the regression logistic model, variables like age, intubation status, pH, and chlorine levels significantly affected the outcome of COVID-19 disease. Patients with acidosis were 4.7 times more likely to die than those with alkalosis (P<0.001). The chance of dying in hyperchloremia is 2.38 times more compared to the normochloremia group (P<0.009). Conclusion: Patients with severe COVID-19 may present with chlorine abnormalities, including hyperchloremia. Hyperchloremia is also associated with poor clinical outcomes and a higher mortality risk. This relationship was independent of acid-base disorder.

Keywords

Intensive care unit (ICU)

Mortality

Assessment of Prevalence and Prognostic Value of Acid-Base and Electrolyte Imbalances in ICU-Admitted Severe COVID-19 Patients

Masood Alaei,

Kimia Taebi,

Sanaz Keshavarz Shahbaz,

Maryam Gheraati,

Monirsadat Mirzadeh,

Negar Sheikhdavoodi

Alaei M, Taebi K, Keshavarz Shahbaz S, Gheraati M, Mirzadeh M, et al. Assessment of Prevalence and Prognostic Value of Acid-Base and Electrolyte Imbalances in ICU-Admitted Severe COVID-19 Patients. J Inflamm Dis. 2024;28(3):e159098. doi: https://doi.org/10.69107/jid-159098

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Shaghayegh Badriahmadi,

Ali Shamshirian,

AmirAli Moodi Ghalibaf,

Mahnaz Mozdourian

Miri M, Badriahmadi S, Shamshirian A, Moodi Ghalibaf A, Mozdourian M. Electrolyte Imbalance and COVID-19 Severity in Hospitalized Patients. Nephro-Urol Mon. 2022;14(3):e128085. doi: https://doi.org/10.5812/numonthly-128085

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Nasim Khajavi Rad,

Narjes Zarei Jalalabadi,

Sahar Karimpour Reyhan

,et al.

Abbaszadeh M, Gorgani F, Javadi Tabrizi S, Khajavi Rad N, Zarei Jalalabadi N, et al. The Prevalence of Electrolyte Imbalances and Their Relationship with Disease Severity in Hospitalized COVID-19 Patients. Arch Clin Infect Dis. 2022;17(3):e112190. doi: https://doi.org/10.5812/archcid-112190

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Comparison of Serum Electrolyte Levels at Admission in COVID-19 Patients Based on Outcomes: A Retrospective Study During the Delta Variant Outbreak

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Maliheh Yarmohamadi,

Abbas Ziari,

Amin Izadi

Asgharnia M, Yarmohamadi M, Ziari A, Izadi A. Comparison of Serum Electrolyte Levels at Admission in COVID-19 Patients Based on Outcomes: A Retrospective Study During the Delta Variant Outbreak. Middle East J Rehabil Health Stud. 2025;12(4):e159350. doi: https://doi.org/10.5812/mejrh-159350

31

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Hyponatremia at Admission in Hospitalized Patients With COVID-19: Risk Factors and Impact on Prognosis

Negar Davoodi,

marayam gheraati,

Sima Hashemipour,

Milad Badri,

Nafiseh Rastgoo,

Aref Shokri

,et al.

Davoodi N, gheraati M, Hashemipour S, Badri M, Rastgoo N, et al. Hyponatremia at Admission in Hospitalized Patients With COVID-19: Risk Factors and Impact on Prognosis. J Inflamm Dis. 2024;25(3):e156286. doi:

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Author(s):

marayam gheraati:[PubMed][Scholar]
Monirsadat Mirzadeh:[PubMed][Scholar]
fateme nazifi:[PubMed][Scholar]
Negar Davoodi:[PubMed][Scholar]
Atefeh Khoshkchali:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

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Dyschloremia During Severe COVID‑19 Infection in Intensive Care Unit Patients

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