Jentashapir Journal of Cellular and Molecular Biology
The goal of this study was the selection of a suitable suspending agent to prepare a stable oral suspension for drug delivery by ion-exchange resins. Suspending agents are used to increase the viscosity of the media to maintain uniform dispersion during storage.
To select the best suspending agent, some formulations with different concentration of HEC, xanthan gum and HPMC were prepared and evaluated for physicochemical characteristics such as sedimentation volume and redispersibility.
Prepared suspensions by HEC and HPMC as suspending agents in low concentrations had low sedimentation volumes and increasing in concentration caused to enhance in sedimentation volume but the redispersibility was difficult. The prepared suspensions using xanthan gum have good sedimentation volume and redispersibility.
© 2012, Jentashapir Journal of Cellular and Molecular Biology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Kouchak M, Atyabi F. Ion-exchange, an Approach to Prepare an Oral Floating Drug Delivery System for Diclofenac. Iran J Pharm Res. 2022;3(2):e128188. doi: https://doi.org/10.22037/ijpr.2010.582
Sharif Makhmal Zadeh B, Salimi A, Amini R. Novel Super Saturated Self- Emulsifying System for Oral Delivery of Griseofulvin Design, Preparation and ex-vivo Intestinal Permeability. J Rep Pharm Sci. 2017;6(2):e147616. doi:
Daravath B, Kumari GP. Improvement of Bioavailability of Poorly Soluble Racecadotril by Solid Dispersion with Surface Adsorption Method: A Case Study. J Rep Pharm Sci. 2021;10(1):e147093. doi: https://doi.org/10.4103/jrptps.JRPTPS_129_19
Tayebi H, Mortazavi SA. Formulation and Evaluation of a Novel Matrix-Type Orally Disintegrating Ibuprofen Tablet. Iran J Pharm Res. 2011;10(3):e125934. doi: https://doi.org/10.22037/ijpr.2011.946
Krishnamoorthy V, Nagalingam A, Priya Ranjan Prasad V, Parameshwaran S, George N, et al. Characterization of Olanzapine-Solid Dispersions. Iran J Pharm Res. 2011;10(1):e125925. doi: https://doi.org/10.22037/ijpr.2010.880
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
