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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
EVALUATION OF THE SWELLING, EROSION AND DRUG RELEASE FROM POLYSACCHARIDE MATRIX TABLETS BASED ON PECTIN AND INULIN
Authors
1Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences-Department of Pharmaceutics, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Iran
2Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences-Department of Pharmaceutics, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, [email protected], Iran
*Corresponding Author: Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences-Department of Pharmaceutics, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, [email protected], Iran. Email: [email protected]
Published online:Nov 30, 2011
Article type:Research Article
Received:Apr 01, 2011
Accepted:Jun 01, 2011
How to Cite:Akhgari A, Abbaspour M, Rezaee S, Kuchak A. EVALUATION OF THE SWELLING, EROSION AND DRUG RELEASE FROM POLYSACCHARIDE MATRIX TABLETS BASED ON PECTIN AND INULIN. Jundishapur J Nat Pharm Prod. 2011;6(1):. doi:
Abstract
The aim of this study was to investigate swelling, erosion and drug release behavior of tablets containing pectin and inulin (polysaccharide) compared with different grades of hydroxy propyl methyl cellulose (HMPC) in the preparation of slow-release tablets. In this study, theophylline was used as a drug model. HPMC K100 and HPMC K4M and high methoxylated pectin were selected as extended release matrix formers. Tablets were prepared by using direct compression. After determination of mechanical properties, swelling, erosion and drug release studies of matrix tablets were carried out in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and distilled water. The results of study showed a pH-dependent formation of hydrogel for the pectin tablets so that swelling of tablets in SIF was much more compared to SGF. Tablets made of HPMC K100 released the total drug in 12 h while drug release from pectin-based tablets at the same time was only 65%. Other formulations released their drug less than 12 h. Among the formulations, tablets containing pectin and HPMC K100 had high swelling, low erosion and slow drug release and therefore they were suitable as extended release systems.
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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