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Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
In silico Comparison of Structural Features and Predicted Epitopes of Envelope Protein of Zika Virus with the Homologous Proteins of Two Closely Related Viruses
Authors
1Dept. of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
Published online:Dec 30, 2017
Article type:Research Article
Received:Jul 31, 2017
Accepted:Nov 07, 2017
How to Cite:Ebrahimi S, Mohabatkar H, Behbahani M. In silico Comparison of Structural Features and Predicted Epitopes of Envelope Protein of Zika Virus with the Homologous Proteins of Two Closely Related Viruses. J Kermanshah Univ Med Sci. 2017;21(3):e69273. doi:
Abstract
Introduction: Of recent, Zika virus (ZIKV) has spread worldwide apart from its original geographical zone (Federated States of Micronesia). Investigations prove a relationship between ZIKV and microcephaly in newborn babies. Research on the essential proteins of this virus may help in preventing its epidemic.
Methods: Herein, the in silico study for envelope protein of ZIKV and two other viruses, that is, dengue virus (DENV) and Spondweni virus (SPOV), was carried out. In the present study, the essential structural properties of the envelope protein of ZIKV were predicted using the bioinformatics tools such as PseAAC, GOR IV, BCPREDS, MHCPred, DiANNA, GlycoEP, and MEGA.
Results: Envelope protein of ZIKV shares certain common features with DENV and SPOV. But our results show that ZIKV has similar structural features as SPOV in comparison to DENV.
Conclusion: By understanding the differences and similarities in these viruses, we may find an appropriate treatment for ZIKV. Also, finding the effectively shared epitopes between the similar viruses could help in finding a common vaccine between these viruses.
Highlights
References
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Copyright
© 2017, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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