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Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013)
Authors
Tayebeh Vaezi1, Zabihollah Shoja2, Shohreh Shahmahmoodi3, Farhad Babaei4, Babak Izadi5, Somayeh Jalilvand1,*
1Dept. of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2Dept. of Virology, Pasteur Institute of Iran, Tehran, Iran
3Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4Dept. of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
5Dept. of Pathology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Somayeh Jalilvand, Dept. of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Tel: +98 2188962343 Email: sjalilvand@tums.ac.ir
Published online:May 31, 2017
Article type:Research Article
Received:Feb 21, 2017
Accepted:May 27, 2017
How to Cite:Vaezi T, Shoja Z, Shahmahmoodi S, Babaei F, Izadi B, et al. The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013). J Kermanshah Univ Med Sci. 2017;21(1):e69511. doi: https://doi.org/10.22110/jkums.v21i1.3479
Abstract
Introduction: It is important to have data on human papillomavirus (HPV) from different geographical regions of Iran for health policymakers to make decisions on national programs of HPV vaccination. Because no study was found on HPV genotyping in Kermanshah Province, this study appeared necessary.
Methods: Fifty-three paraffin-embedded cervical tissue samples were collected. All samples were evaluated by polymerase chain reaction (PCR) or nested-polymerase chain reaction assays with specific primers designed for L1 gene. Positive samples were subjected to sequence and phylogenic tree analysis.
Results: Thirty-one out of 53 samples (58.5%) were found to be HPV positive. Prominent HPV genotype was HPV16 followed by HPV6, 31 and 53. Based on the histology of cervicitis, only HPV16 was found both in cervicitis and adenocarcinoma while HPV6 and 16 were found in cervical intraepithelial neoplasia I, and HPV6 and 53 were found in cervical intraepithelial neoplasia II. HPV16 and 31 were also found in squamous cell carcinoma.
Discussion: Findings from this study support a strong correlation of HPV16 as a leading cause of cervical cancer in this region. It appears that HPV vaccines could drastically reduce the incidence of cervical cancer.
Highlights
References
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Copyright
© 2017, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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