Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice
Authors
Shahram Vosoughi1, Hassan Asilian Mahabadi2,*, Ali Khavanin2, Mojdeh Salehnia3, Abdolhossein Shahverdi4, Vahid Esmaeili4, Ardalan Soleimanian2
1Dept. of Health Sciences, School of Health, Safety and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Dept. of Occupational and Environmental Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Dept. of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4Embryology Department, Reproductive Biomedicine Research Center, Royan Institute, ACECR, Tehran, Iran
*Corresponding Author: Corresponding author: Hassan Asilian Mahabadi, Dept. of Occupational and Environmental Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran, Tel: +98 21 82883849 Email: Asiliah@modares.ac.ir
Published online:Mar 29, 2013
Article type:Research Article
Received:Apr 10, 2012
Accepted:Jul 24, 2012
How to Cite:Vosoughi S, Asilian Mahabadi H, Khavanin A, Salehnia M, Shahverdi A, et al. Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice. J Kermanshah Univ Med Sci. 2013;16(8):e77270. doi:
Abstract
Background: Formaldehyde (H2C = O), is a member of aldehyde family with a simplest organic molecule, used in various industries. The aim of this experimental study was to investigate the effects of simultaneous formaldehyde and noise exposure on hormonal pituitary-gonadal axis in adult male mice.
Methods: 46 adult male mice were randomly assigned to one control group and three experimental groups which were exposed to formaldehyde vapor (10 ppm) (F), noise (100 dB) (N), and simultaneous formaldehyde with noise (NF), respectively for 10 days (8 hours a day). At the end of the experiment half of the mice of each group were sacrificed 24 hours after exposure (short-term effects) and the rest were sacrificed 35 days after the end of exposure (long-term effects). Plasma concentrations of testosterone, LH, FSH were measured using the ELISA method.
Results: In short-term analysis, the serum testosterone in groups N, F, and NF were 2.73±0.24, 2.58±0.16, and 2.03±0.22,(Ng/ml)respectively which had a significant decrease (p<0.001)compared to control group(3.82±0.35). The LH level in groups F, and NF also showed significant reduction compared to control group (p<0.05 and p<0.001).
Conclusion: Reduction of serum testosterone and LH level may be potentiated by noise (700-5700 HZ) in the simultaneous exposure to formaldehyde and noise.
Highlights
References
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Copyright
© 2013, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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