Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
An investigation into the effect of exogenous melatonin on spermatogenesis of pinealectomised busulfan induced oligospermic adult rats
Authors
Ahad Ferdosi Khosoroshahi1, Jafar Solimanirad1, Seyed Behnamedin Jameie2,*, Mehrdad Bakhtiari2, Seyed Morteza Kruji2, Leila Roshangar1, Mohamad Taghi Joghataei2
1Dept. of Anatomy, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Seyed Behnamedin Jameie, Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Tel: +982188622585 Email: behnamjameie@tums.ac.ir
Published online:Jan 29, 2013
Article type:Research Article
Received:Jan 05, 2012
Accepted:Jun 05, 2012
How to Cite:Ferdosi Khosoroshahi A, Solimanirad J, Jameie SB, Bakhtiari M, Kruji SM, et al. An investigation into the effect of exogenous melatonin on spermatogenesis of pinealectomised busulfan induced oligospermic adult rats. J Kermanshah Univ Med Sci. 2013;16(6):e77335. doi:
Abstract
Background: Damage to Spermatogenic and fertility disorders are among major side effects of chemotography drugs such as busulfan. To reduce the side effects of these drugs different methods such as protecting and fixing germinal cell epithelium, while employing chemotherapy are used. The aim of this study was to investigate the effect of exogenous melatonin on the treatment of oligospermic in spermatogenesis.
Methods: Sixty adult Wistar rats were used and randomly divided into 6 groups: 1-the control group, 2-recipient busulfan, 3-recipient of the DMSO (Vehicle busulfan) , 4-surgical sham group, 5-Pinealectomized, recipient busulfan and ethanol (Vehicle melatonin), 6-Pinealectomized, recipient busulfan and melatonin as experimental group. Single dose of busulfan (20mg/kg) and melatonin (0.5mg/kg) for 60 days were used by IP injection.
Results: Busulfan significantly reduced sperm parameters (number, motility, form and size) in comparison with that of control group (p<0.05). However, in combined treatment in comparison with recipient busulfan group, melatonin treated germinal cell epithelium and created a Spermatogenic cell mass in the seminiferous tubules.
Conclusion: Melatonin has a protective effect on spermatogenesis via unknown mechanism. It seems that decreasing oxidative damage interfere in this mechanism.
Highlights
References
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Copyright
© 2013, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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