Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
The effect of dopamine D2 receptors of the dorsal hippocampus on the Histamine-induced anxiety behavior in mice
Authors
1Dept. of Biology, School of Sciences, Islamic Azad University, Ardabil Branch, Ardabil, Iran
2Dept. of Biology, School of Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
3Dept. of Biology, School of Sciences, Islamic Azad University, Rey Branch, Tehran, Iran
*Corresponding Author: Corresponding author: Morteza Piri, Dept. of Biology, School of Sciences, Islamic Azad University, Ardabil Branch, Ardabil, Iran, Tel: +98 9122543585 Email: biopiri@iauardabil.ac.ir
Published online:Sep 29, 2012
Article type:Research Article
Received:May 30, 2011
Accepted:Nov 01, 2011
How to Cite:Piri M, Ayazi E, Bananej M, Shahin M. The effect of dopamine D2 receptors of the dorsal hippocampus on the Histamine-induced anxiety behavior in mice. J Kermanshah Univ Med Sci. 2012;16(3):e78797. doi:
Abstract
Background: High levels of histamine and dopamine are found in the hippocampus. Furthermore, interaction between histamine and dopaminergic D2 receptors has been demonstrated in the modulation of some behaviors. In the present study, interaction between histamine and dopaminergic D2 receptor in the dorsal hippocampus in the anxiety behavior has been investigated.
Methods: In this experimental study, 220 adult male NMRI mice were anesthetized and then placed in a stereotaxic apparatus. Two stainless-steel cannuale were placed in the CA1 region of hippocampus. The elevated plus maze test has been used to test anxiety-like behaviors. Two and one-way analyses of variance (ANOVAs) followed by LSD test, were used for analysis of the data. All experiments were performed in accordance with institutional guidelines for animal care and use.
Results: Intra-CA1 injection of histamine and dopamine D2 agonist (quinpirole) and antagonist (sulpiride) induced anxiety. Intra-CA1 injection quinpirole or sulpiride 2 minute after effective dose of histamine inhibited anxiogenic effects of histamine.
Conclusion: It seems that both histamine and dopaminergic D2 receptors not only play a part in the modulation of anxiety in the dorsal hippocampus of mice but also have demonstrated a complex interaction.
Highlights
References
- 1.The references of this article is available on PDF.
Copyright
© 2012, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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