Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
The effect of sodium salicylate injection on spatial learning and memory of rat
Authors
1Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Ali Pourmotabbed, Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +98 831 427 4618 Email: apourmotabbed@kums.ac.ir
Published online:Jan 19, 2012
Article type:Research Article
Received:Nov 24, 2010
Accepted:Apr 26, 2011
How to Cite:Azimi L, Pourmotabbed A, Nedaei SE, Ghadami MR. The effect of sodium salicylate injection on spatial learning and memory of rat. J Kermanshah Univ Med Sci. 2012;15(5):e79015. doi:
Abstract
Background: Cyclooxygenase (COX) enzyme known as a regulatory factor in synaptic plasticity. It has been reported that synaptic plasticity is one of the mechanisms involved in learning and memory processes. In the current study peripheral injection's effects of sodium salicylate (as a non selective COX inhibitor) on spatial learning and memory have been investigated.
Methods: Four groups of male rats received different doses of sodium salicylate (0, 200, 300, 400 mg/kg; i.p.). Studies were performed using Morris Water Maze (MWM). Spatial learning and memory parameters were subjected to the one- and two-way analyses of variance (ANOVAs) followed by Tukey’s post hoc test.
Results: Data showed that intraperitoneal injection of sodium salicylate had not significant effect on spatial learning parameters (including escape latency and traveled distance to hidden platform in training days); but administration of high dose of the drug (400 mg/kg) significantly increased the percentage of time that animals spent in the target quadrant in probe trial testing.
Conclusion: Peripheral injection of the COX inhibitor has no significant effect on spatial learning; but potentiates spatial memory consolidation using MWM.
Highlights
References
- 1.The references of this article is available on PDF.
Copyright
© 2012, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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