The effect of intravenous immunoglobulin on admission duration and mortality rate related to sepsis in preterm neonates

Homa Babaei; Ali Asghar Alipour; KeiGhobad Ghadiri; Amir Masoud Abdollahzadeh; Mansour Rezaei

Journal of Kermanshah University of Medical Sciences

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The effect of intravenous immunoglobulin on admission duration and mortality rate related to sepsis in preterm neonates

Author(s):

Homa Babaei^1,*,

Ali Asghar Alipour¹,

KeiGhobad Ghadiri¹,

Amir Masoud Abdollahzadeh²,

Mansour Rezaei³

1Dept. of Pediatrics, School of Medicine, Kermanshah university of Medical Sciences, Kermanshah, Iran

2Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Dept. of Biostatistics, School of Health, Kermanshah university of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 15, issue 5; e79018

Published online:Jan 19, 2012

Article type:Research Article

Received:Jan 18, 2011

Accepted:Jun 21, 2011

How to Cite:Babaei H, Alipour AA, Ghadiri K, Abdollahzadeh AM, Rezaei M. The effect of intravenous immunoglobulin on admission duration and mortality rate related to sepsis in preterm neonates. J Kermanshah Univ Med Sci. 2012;15(5):e79018. doi:

Abstract

Background: The infection in the neonatal period is a significant cause of mortality in the preterm neonates. The transfer of the immunoglobulin from mother to fetus occurs mainly after 32 to 34 weeks of gestation. Therefore, preterm neonates are relatively immune compromised. The aim of the study was to evaluate the impact of intravenous immunoglobulin on mortality rates reduction in preterm neonates.

Methods: A randomised clinical trial coducted from Jan2008 to July 2009 in Imam Reza hospital of Kermanshah - Iran. The population was 40 preterm neonates with gestational age less than 34 weeks admitted in the NICU with probable sepsis (clinical sepsis + Lab test). They have been divided into two case and control groups with 20 subjects in each group. The case group received 500 mg/kg intravenous immunoglobulin during first 24 hours of admission in addition to routine treatments, which were the same in both group. Before and 6 hours after administration of intravenous immunoglobulin serum level of IgG was measured in treatment group. Then data were analyzed with SPSS software and Fisher's exact test and X² test were analyzed.

Results: Mortality rate was higher in control than treatment group, but it was no statistically significan. There were not significant differences in variables including the need for ventilation, exchange transfusion, admission duration and positive blood culture. Serum IgG levels significantly increased after administration of immunoglobulin in treatment group (p=0.001).

Conclusion: Useing intravenous immunoglobulin in the treatment of sepsis increased serum level of IgG but did not effect on mortality rate and admission duration in preterm neonates.

Keywords

intravenous immunoglobulin

neonatal mortality

preterm neonates

blood infection

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References

1.
The references of this article is available on PDF.

Severe Gastrointestinal Complications After IVIG Infusion in Newborns: A Two-Center Study and Literature Review

Ibrahim Kandemir,

Akan Yaman,

Bilal Dinc,

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Kandemir I, Yaman A, Dinc B, Gulcan Kersin S, Selva Bilgen H. Severe Gastrointestinal Complications After IVIG Infusion in Newborns: A Two-Center Study and Literature Review. Inn J Pediatr. 2024;34(2):e144488. doi: https://doi.org/10.5812/ijp-144488

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2019

Clinical and Biochemical Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on the Prognosis of Preterm Infants with Early Onset Neonatal Sepsis

Reza Saeidi,

Hossein Akhavan,

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2025

The Effect of Probiotics on Health Outcome in Preterm Infants: A Randomized Clinical Trial

Gholam Reza Faal,

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Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis

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Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis

Roya Oboodi,

Zahra Hashemi,

Elham Jaafarzadeh,

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Hamide Barzegar

Oboodi R, Hashemi Z, Jaafarzadeh E, Yazdani N, Barzegar H. Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis. Arch Pediatr Infect Dis. 2024;12(1):e136487. doi: https://doi.org/10.5812/apid-136487

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Author(s):

Homa Babaei:[PubMed][Scholar]
Ali Asghar Alipour:[PubMed][Scholar]
KeiGhobad Ghadiri:[PubMed][Scholar]
Amir Masoud Abdollahzadeh:[PubMed][Scholar]
Mansour Rezaei:[PubMed][Scholar]

Peer-reviewed Medical Quarterly

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The effect of intravenous immunoglobulin on admission duration and mortality rate related to sepsis in preterm neonates

Abstract

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References

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